eF-site ID 6nn7-D PDB Code 6nn7 Chain D click to enlarge Title The structure of human liver pyruvate kinase, hLPYK-GGG Classification TRANSFERASE Compound Pyruvate kinase PKLR Source (KPYR_HUMAN) Sequence D:  AFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIAT IGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIAN VREAVESFAGSPLSYRPVAIALDTKGPEIRTGSEVELVKL VTVDPRGNANTVWVDYPNIVVPIYIDDGLISLQKINGGVL GSRKGVNLPLSEQDVRDLRFGVEHGVDIVFASFVRKASDV AAVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIM VARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQML ESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFP VEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEV TAIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVI AVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQ FGIESGKLRGFLRVGDLVIVVTGWRGGGYTNIMRVLSIS Description Functional site 1) chain D residue 354 type sequence R description binding site for residue EDO C 605 source : AD4 2) chain D residue 357 type sequence T description binding site for residue EDO C 605 source : AD4 3) chain D residue 69 type sequence S description binding site for residue EDO E 601 source : AD9 4) chain D residue 421 type sequence T description binding site for residue FLC D 601 source : AE5 5) chain D residue 444 type sequence T description binding site for residue FLC D 601 source : AE5 6) chain D residue 445 type sequence T description binding site for residue FLC D 601 source : AE5 7) chain D residue 446 type sequence T description binding site for residue FLC D 601 source : AE5 8) chain D residue 448 type sequence R description binding site for residue FLC D 601 source : AE5 9) chain D residue 449 type sequence S description binding site for residue FLC D 601 source : AE5 10) chain D residue 69 type sequence S description binding site for residue EDO D 602 source : AE6 11) chain D residue 72 type sequence R description binding site for residue EDO D 602 source : AE6 12) chain D residue 85 type sequence R description binding site for residue GOL D 603 source : AE7 13) chain D residue 284 type sequence E description binding site for residue GOL D 603 source : AE7 14) chain D residue 305 type sequence A description binding site for residue GOL D 603 source : AE7 15) chain D residue 308 type sequence D description binding site for residue GOL D 603 source : AE7 16) chain D residue 89 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 17) chain D residue 85 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 18) chain D residue 87 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 19) chain D residue 125 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 20) chain D residue 126 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 21) chain D residue 282 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 22) chain D residue 284 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 23) chain D residue 307 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 24) chain D residue 308 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 25) chain D residue 340 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 26) chain D residue 444 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 27) chain D residue 494 type BINDING sequence W description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 28) chain D residue 501 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 29) chain D residue 528 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 30) chain D residue 219 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 31) chain D residue 132 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 32) chain D residue 282 type SITE sequence K description Transition state stabilizer => ECO:0000250|UniProtKB:P00549 source Swiss-Prot : SWS_FT_FI4 33) chain D residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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