eF-site ID 6nn7-C PDB Code 6nn7 Chain C click to enlarge Title The structure of human liver pyruvate kinase, hLPYK-GGG Classification TRANSFERASE Compound Pyruvate kinase PKLR Source (KPYR_HUMAN) Sequence C:  QQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPA SRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVREA VESFAGSPYRPVAIALDTKGPEIRTGILQGGPESEVELVK GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYI DDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQV DLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGD LGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMIT KPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGA VEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRS AQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIES GKLRGFLRVGDLVIVVTGWRGGGYTNIMRVLSIS Description Functional site 1) chain C residue 421 type sequence T description binding site for residue FLC C 601 source : AC9 2) chain C residue 444 type sequence T description binding site for residue FLC C 601 source : AC9 3) chain C residue 445 type sequence T description binding site for residue FLC C 601 source : AC9 4) chain C residue 446 type sequence T description binding site for residue FLC C 601 source : AC9 5) chain C residue 448 type sequence R description binding site for residue FLC C 601 source : AC9 6) chain C residue 449 type sequence S description binding site for residue FLC C 601 source : AC9 7) chain C residue 534 type sequence T description binding site for residue FLC C 601 source : AC9 8) chain C residue 93 type sequence H description binding site for residue EDO C 602 source : AD1 9) chain C residue 247 type sequence H description binding site for residue EDO C 602 source : AD1 10) chain C residue 104 type sequence R description binding site for residue EDO C 603 source : AD2 11) chain C residue 122 type sequence I description binding site for residue EDO C 603 source : AD2 12) chain C residue 248 type sequence G description binding site for residue EDO C 603 source : AD2 13) chain C residue 249 type sequence V description binding site for residue EDO C 603 source : AD2 14) chain C residue 250 type sequence D description binding site for residue EDO C 603 source : AD2 15) chain C residue 473 type sequence R description binding site for residue EDO C 603 source : AD2 16) chain C residue 278 type sequence K description binding site for residue EDO C 604 source : AD3 17) chain C residue 451 type sequence Q description binding site for residue EDO C 604 source : AD3 18) chain C residue 474 type sequence Q description binding site for residue EDO C 604 source : AD3 19) chain C residue 306 type sequence R description binding site for residue EDO C 605 source : AD4 20) chain C residue 318 type sequence V description binding site for residue EDO C 605 source : AD4 21) chain C residue 319 type sequence F description binding site for residue EDO C 605 source : AD4 22) chain C residue 322 type sequence Q description binding site for residue EDO C 605 source : AD4 23) chain C residue 129 type sequence P description binding site for residue EDO C 606 source : AD5 24) chain C residue 221 type sequence V description binding site for residue EDO C 606 source : AD5 25) chain C residue 256 type sequence F description binding site for residue EDO C 606 source : AD5 26) chain C residue 137 type sequence Q description binding site for residue EDO C 607 source : AD6 27) chain C residue 165 type sequence N description binding site for residue EDO C 607 source : AD6 28) chain C residue 351 type sequence R description binding site for residue EDO C 608 source : AD7 29) chain C residue 85 type sequence R description binding site for residue GOL C 609 source : AD8 30) chain C residue 282 type sequence K description binding site for residue GOL C 609 source : AD8 31) chain C residue 305 type sequence A description binding site for residue GOL C 609 source : AD8 32) chain C residue 307 type sequence G description binding site for residue GOL C 609 source : AD8 33) chain C residue 308 type sequence D description binding site for residue GOL C 609 source : AD8 34) chain C residue 340 type sequence T description binding site for residue GOL C 609 source : AD8 35) chain C residue 528 type sequence R description binding site for residue GOL E 603 source : AE2 36) chain C residue 275 type sequence H description binding site for residue GOL E 604 source : AE3 37) chain C residue 85 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 38) chain C residue 89 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 39) chain C residue 87 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 40) chain C residue 125 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 41) chain C residue 126 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 42) chain C residue 282 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 43) chain C residue 284 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 44) chain C residue 307 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 45) chain C residue 308 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 46) chain C residue 340 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 47) chain C residue 444 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 48) chain C residue 494 type BINDING sequence W description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 49) chain C residue 501 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 50) chain C residue 528 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 51) chain C residue 132 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 52) chain C residue 219 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 53) chain C residue 282 type SITE sequence K description Transition state stabilizer => ECO:0000250|UniProtKB:P00549 source Swiss-Prot : SWS_FT_FI4 54) chain C residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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