eF-site ID 6nji-A PDB Code 6nji Chain A click to enlarge Title Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-49 Classification HYDROLASE/HYDROLASE INHIBITOR Compound cAMP-specific 3',5'-cyclic phosphodiesterase 4D Source (PDE4D_HUMAN) Sequence A:  EQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIF QERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAA DVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPG VSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENC DIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTM VETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPL QLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVE KSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWY QSTIPQNQVSEFISNTFLD Description Functional site 1) chain A residue 330 type sequence H description binding site for residue ZN A 700 source : AC1 2) chain A residue 366 type sequence H description binding site for residue ZN A 700 source : AC1 3) chain A residue 367 type sequence D description binding site for residue ZN A 700 source : AC1 4) chain A residue 484 type sequence D description binding site for residue ZN A 700 source : AC1 5) chain A residue 367 type sequence D description binding site for residue MG A 701 source : AC2 6) chain A residue 487 type sequence N description binding site for residue KR4 A 702 source : AC3 7) chain A residue 499 type sequence T description binding site for residue KR4 A 702 source : AC3 8) chain A residue 535 type sequence Q description binding site for residue KR4 A 702 source : AC3 9) chain A residue 538 type sequence F description binding site for residue KR4 A 702 source : AC3 10) chain A residue 599 type sequence F description binding site for residue KR4 A 702 source : AC3 11) chain A residue 366-377 type prosite sequence HDVDHPGVSNQF description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF source prosite : PS00126

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