eF-site ID 6njh-D PDB Code 6njh Chain D click to enlarge Title Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-48 Classification HYDROLASE/HYDROLASE INHIBITOR Compound cAMP-specific 3',5'-cyclic phosphodiesterase 4D Source (PDE4D_HUMAN) Sequence D:  EDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQE RDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADV VQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVS NQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDI FQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVE TKKVTVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQ WTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVG FIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP NQVSEFISNTFLD Description Functional site 1) chain D residue 384 type sequence E description binding site for residue MG D 701 source : AD2 2) chain D residue 330 type sequence H description binding site for residue ZN D 702 source : AD3 3) chain D residue 366 type sequence H description binding site for residue ZN D 702 source : AD3 4) chain D residue 367 type sequence D description binding site for residue ZN D 702 source : AD3 5) chain D residue 484 type sequence D description binding site for residue ZN D 702 source : AD3 6) chain D residue 367 type sequence D description binding site for residue MG D 703 source : AD4 7) chain D residue 326 type sequence H description binding site for residue KRD D 704 source : AD5 8) chain D residue 374 type sequence S description binding site for residue KRD D 704 source : AD5 9) chain D residue 487 type sequence N description binding site for residue KRD D 704 source : AD5 10) chain D residue 498 type sequence W description binding site for residue KRD D 704 source : AD5 11) chain D residue 499 type sequence T description binding site for residue KRD D 704 source : AD5 12) chain D residue 523 type sequence M description binding site for residue KRD D 704 source : AD5 13) chain D residue 535 type sequence Q description binding site for residue KRD D 704 source : AD5 14) chain D residue 538 type sequence F description binding site for residue KRD D 704 source : AD5 15) chain D residue 599 type sequence F description binding site for residue KRD D 704 source : AD5 16) chain D residue 387 type ACT_SITE sequence L description Proton donor => ECO:0000250|UniProtKB:Q07343 source Swiss-Prot : SWS_FT_FI1 17) chain D residue 387 type BINDING sequence L description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 18) chain D residue 548 type BINDING sequence E description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 source Swiss-Prot : SWS_FT_FI2 19) chain D residue 391 type BINDING sequence D description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI3 20) chain D residue 427 type BINDING sequence R description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 21) chain D residue 545 type BINDING sequence P description BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 source Swiss-Prot : SWS_FT_FI4 22) chain D residue 428 type BINDING sequence K description BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW source Swiss-Prot : SWS_FT_FI5 23) chain D residue 273 type MOD_RES sequence F description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 24) chain D residue 300 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI6 25) chain D residue 312 type CROSSLNK sequence L description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) source Swiss-Prot : SWS_FT_FI7

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