eF-site ID 6nig-ABCD
PDB Code 6nig
Chain A, B, C, D

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Title Crystal structure of the human TLR2-Diprovocim complex
Classification IMMUNE SYSTEM/AGONIST
Compound Toll-like receptor 2,Variable lymphocyte receptor B
Source (Q2YE02_EPTST)
Sequence A:  SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITY
ISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLD
LSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFS
HLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDL
QSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVEC
LELRDTDLDTFHFSELSTNSLIKKFTFRNVKITDESLFQV
MKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKV
ETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVF
LVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSL
QTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMP
ETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNL
NLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRN
QLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWL
NKNSQKEQGSAKCSGSGKPVRSIICP
B:  SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITY
ISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLD
LSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFS
HLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDL
QSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVEC
LELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESL
FQVMKLLNQISGLLELEFDDCTLNGVGNFRASDIDPGKVE
TLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFL
VPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQ
TLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPE
TCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLN
LFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNQ
LKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWLN
KNSQKEQGSAKCSGSGKPVRSIICP
C:  SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITY
ISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLD
LSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFS
HLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDL
QSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVEC
LELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESL
FQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDP
GKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENS
KVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAW
PSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFH
SMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSN
NNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKI
SRNQLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLS
RWLNKNSQKEQGSAKCSGSGKPVRSIICP
D:  SLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITY
ISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLD
LSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFS
HLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDL
QSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVEC
LELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESL
FQVMKLLNQISGLLELEFDDCTLNGVGNFRASDVIDPGKV
ETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVF
LVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSL
QTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMP
ETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNL
NLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRN
QLKSVPDGIFDRLTSLQKIWLHTNPWDCSCPRIDYLSRWL
NKNSQKEQGSAKCSGSGKPVRSIICP
Description


Functional site

1) chain A
residue 349
type SITE
sequence F
description Interaction with bacterial lipopeptide
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 349
type SITE
sequence F
description Interaction with bacterial lipopeptide
source Swiss-Prot : SWS_FT_FI1

3) chain C
residue 349
type SITE
sequence F
description Interaction with bacterial lipopeptide
source Swiss-Prot : SWS_FT_FI1

4) chain D
residue 349
type SITE
sequence F
description Interaction with bacterial lipopeptide
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 114
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

6) chain D
residue 114
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

7) chain D
residue 199
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

8) chain D
residue 442
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

9) chain A
residue 199
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 442
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

11) chain B
residue 114
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

12) chain B
residue 199
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

13) chain B
residue 442
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

14) chain C
residue 114
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

15) chain C
residue 199
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

16) chain C
residue 442
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15173186, ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 414
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI3

18) chain B
residue 414
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI3

19) chain C
residue 414
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI3

20) chain D
residue 414
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17889651
source Swiss-Prot : SWS_FT_FI3


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