eF-site ID 6nhe-AB PDB Code 6nhe Chain A, B click to enlarge Title Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(5-(2-((2S,4R)-4-ethoxy-1-methylpyrrolidin-2-yl)ethyl)-2,3-difluorophenethyl)-4-methylpyridin-2-amine Classification OXIDOREDUCTASE Compound Nitric oxide synthase, brain Source (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP SQHTRDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRL EEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQW SKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITI FPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQF TEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELV LEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSA CPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKT SSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKH MENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLT PSFEYQPDPWNTHVW B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP SQHTRVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLE EVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWS KLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIF PQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFT EICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVL EVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSAC PFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTS SLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHM ENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTP SFEYQPDPWNTHVWKG Description Functional site 1) chain A residue 341 type sequence H description binding site for residue HEM A 801 source : AC1 2) chain A residue 409 type sequence W description binding site for residue HEM A 801 source : AC1 3) chain A residue 414 type sequence R description binding site for residue HEM A 801 source : AC1 4) chain A residue 415 type sequence C description binding site for residue HEM A 801 source : AC1 5) chain A residue 584 type sequence F description binding site for residue HEM A 801 source : AC1 6) chain A residue 585 type sequence S description binding site for residue HEM A 801 source : AC1 7) chain A residue 587 type sequence W description binding site for residue HEM A 801 source : AC1 8) chain A residue 589 type sequence M description binding site for residue HEM A 801 source : AC1 9) chain A residue 706 type sequence Y description binding site for residue HEM A 801 source : AC1 10) chain A residue 334 type sequence S description binding site for residue H4B A 802 source : AC2 11) chain A residue 596 type sequence R description binding site for residue H4B A 802 source : AC2 12) chain A residue 677 type sequence V description binding site for residue H4B A 802 source : AC2 13) chain A residue 678 type sequence W description binding site for residue H4B A 802 source : AC2 14) chain B residue 676 type sequence W description binding site for residue H4B A 802 source : AC2 15) chain B residue 691 type sequence F description binding site for residue H4B A 802 source : AC2 16) chain B residue 692 type sequence H description binding site for residue H4B A 802 source : AC2 17) chain B residue 694 type sequence E description binding site for residue H4B A 802 source : AC2 18) chain A residue 336 type sequence M description binding site for residue KNS A 803 source : AC3 19) chain A residue 565 type sequence P description binding site for residue KNS A 803 source : AC3 20) chain A residue 567 type sequence V description binding site for residue KNS A 803 source : AC3 21) chain A residue 570 type sequence M description binding site for residue KNS A 803 source : AC3 22) chain A residue 584 type sequence F description binding site for residue KNS A 803 source : AC3 23) chain A residue 586 type sequence G description binding site for residue KNS A 803 source : AC3 24) chain A residue 587 type sequence W description binding site for residue KNS A 803 source : AC3 25) chain A residue 588 type sequence Y description binding site for residue KNS A 803 source : AC3 26) chain A residue 592 type sequence E description binding site for residue KNS A 803 source : AC3 27) chain A residue 706 type sequence Y description binding site for residue KNS A 803 source : AC3 28) chain A residue 417 type sequence G description binding site for residue ACT A 804 source : AC4 29) chain A residue 587 type sequence W description binding site for residue ACT A 804 source : AC4 30) chain A residue 326 type sequence C description binding site for residue ZN A 805 source : AC5 31) chain A residue 331 type sequence C description binding site for residue ZN A 805 source : AC5 32) chain B residue 326 type sequence C description binding site for residue ZN A 805 source : AC5 33) chain B residue 331 type sequence C description binding site for residue ZN A 805 source : AC5 34) chain B residue 341 type sequence H description binding site for residue HEM B 801 source : AC6 35) chain B residue 409 type sequence W description binding site for residue HEM B 801 source : AC6 36) chain B residue 412 type sequence A description binding site for residue HEM B 801 source : AC6 37) chain B residue 414 type sequence R description binding site for residue HEM B 801 source : AC6 38) chain B residue 415 type sequence C description binding site for residue HEM B 801 source : AC6 39) chain B residue 584 type sequence F description binding site for residue HEM B 801 source : AC6 40) chain B residue 585 type sequence S description binding site for residue HEM B 801 source : AC6 41) chain B residue 586 type sequence G description binding site for residue HEM B 801 source : AC6 42) chain B residue 587 type sequence W description binding site for residue HEM B 801 source : AC6 43) chain B residue 589 type sequence M description binding site for residue HEM B 801 source : AC6 44) chain B residue 678 type sequence W description binding site for residue HEM B 801 source : AC6 45) chain B residue 704 type sequence F description binding site for residue HEM B 801 source : AC6 46) chain B residue 706 type sequence Y description binding site for residue HEM B 801 source : AC6 47) chain A residue 676 type sequence W description binding site for residue H4B B 802 source : AC7 48) chain A residue 691 type sequence F description binding site for residue H4B B 802 source : AC7 49) chain A residue 692 type sequence H description binding site for residue H4B B 802 source : AC7 50) chain A residue 693 type sequence Q description binding site for residue H4B B 802 source : AC7 51) chain A residue 694 type sequence E description binding site for residue H4B B 802 source : AC7 52) chain B residue 334 type sequence S description binding site for residue H4B B 802 source : AC7 53) chain B residue 596 type sequence R description binding site for residue H4B B 802 source : AC7 54) chain B residue 677 type sequence V description binding site for residue H4B B 802 source : AC7 55) chain B residue 678 type sequence W description binding site for residue H4B B 802 source : AC7 56) chain B residue 567 type sequence V description binding site for residue KNS B 803 source : AC8 57) chain B residue 570 type sequence M description binding site for residue KNS B 803 source : AC8 58) chain B residue 584 type sequence F description binding site for residue KNS B 803 source : AC8 59) chain B residue 586 type sequence G description binding site for residue KNS B 803 source : AC8 60) chain B residue 587 type sequence W description binding site for residue KNS B 803 source : AC8 61) chain B residue 592 type sequence E description binding site for residue KNS B 803 source : AC8 62) chain B residue 706 type sequence Y description binding site for residue KNS B 803 source : AC8 63) chain B residue 417 type sequence G description binding site for residue ACT B 804 source : AC9 64) chain B residue 420 type sequence Q description binding site for residue ACT B 804 source : AC9 65) chain B residue 587 type sequence W description binding site for residue ACT B 804 source : AC9 66) chain B residue 649 type sequence V description binding site for residue ACT B 804 source : AC9 67) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 68) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 69) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 70) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 71) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 72) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 73) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 74) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 75) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 76) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 77) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 78) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 79) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 80) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 81) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 82) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 83) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 84) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 86) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 87) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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