eF-site ID 6ngn-B PDB Code 6ngn Chain B click to enlarge Title Structure of rat neuronal nitric oxide synthase heme domain in complex with (S)-6-(3-fluoro-5-(2-(pyrrolidin-2-yl)ethyl)phenethyl)-4-methylpyridin-2-amine Classification oxidoreductase/oxidoreductase inhibitor Compound Nitric oxide synthase, brain Source (NOS1_RAT) Sequence B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWKG Description Functional site 1) chain B residue 676 type sequence W description binding site for residue H4B A 802 source : AC2 2) chain B residue 691 type sequence F description binding site for residue H4B A 802 source : AC2 3) chain B residue 692 type sequence H description binding site for residue H4B A 802 source : AC2 4) chain B residue 694 type sequence E description binding site for residue H4B A 802 source : AC2 5) chain B residue 409 type sequence W description binding site for residue HEM B 801 source : AC5 6) chain B residue 412 type sequence A description binding site for residue HEM B 801 source : AC5 7) chain B residue 414 type sequence R description binding site for residue HEM B 801 source : AC5 8) chain B residue 415 type sequence C description binding site for residue HEM B 801 source : AC5 9) chain B residue 584 type sequence F description binding site for residue HEM B 801 source : AC5 10) chain B residue 585 type sequence S description binding site for residue HEM B 801 source : AC5 11) chain B residue 587 type sequence W description binding site for residue HEM B 801 source : AC5 12) chain B residue 592 type sequence E description binding site for residue HEM B 801 source : AC5 13) chain B residue 678 type sequence W description binding site for residue HEM B 801 source : AC5 14) chain B residue 704 type sequence F description binding site for residue HEM B 801 source : AC5 15) chain B residue 706 type sequence Y description binding site for residue HEM B 801 source : AC5 16) chain B residue 334 type sequence S description binding site for residue H4B B 802 source : AC6 17) chain B residue 336 type sequence M description binding site for residue H4B B 802 source : AC6 18) chain B residue 596 type sequence R description binding site for residue H4B B 802 source : AC6 19) chain B residue 677 type sequence V description binding site for residue H4B B 802 source : AC6 20) chain B residue 678 type sequence W description binding site for residue H4B B 802 source : AC6 21) chain B residue 567 type sequence V description binding site for residue KL4 B 803 source : AC7 22) chain B residue 570 type sequence M description binding site for residue KL4 B 803 source : AC7 23) chain B residue 586 type sequence G description binding site for residue KL4 B 803 source : AC7 24) chain B residue 587 type sequence W description binding site for residue KL4 B 803 source : AC7 25) chain B residue 592 type sequence E description binding site for residue KL4 B 803 source : AC7 26) chain B residue 706 type sequence Y description binding site for residue KL4 B 803 source : AC7 27) chain B residue 419 type sequence I description binding site for residue ACT B 804 source : AC8 28) chain B residue 587 type sequence W description binding site for residue ACT B 804 source : AC8 29) chain B residue 649 type sequence V description binding site for residue ACT B 804 source : AC8 30) chain B residue 326 type sequence C description binding site for residue ZN B 805 source : AC9 31) chain B residue 331 type sequence C description binding site for residue ZN B 805 source : AC9 32) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2

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