|
|
eF-site ID
|
6nea-B |
|
PDB Code
|
6nea |
|
Chain
|
B |
|
click to enlarge
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Title
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Human Acetylcholinesterase in complex with reactivator, HLo7 |
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Classification
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HYDROLASE |
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Compound
|
Acetylcholinesterase |
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Source
|
(ACES_HUMAN) |
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Sequence
|
B: |
DAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGP
RRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTE
MWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFY
SGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGS
REAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESA
GAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEA
RRRATQLAHLVGCPNDTELVACLRTRPAQVLVNHEWHVLP
QESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVGV
VKDEGSYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQV
SDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCP
VAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPHGYE
IEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPN
EPAPQWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNR
FLPKLLSA
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Description
|
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Functional site
|
|
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1)
|
chain |
B |
| residue |
265 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
2)
|
chain |
B |
| residue |
86 |
| type |
BINDING |
| sequence |
W
|
| description |
BINDING => ECO:0007744|PDB:4EY5
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
B |
| residue |
133 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0007744|PDB:4EY5
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
B |
| residue |
337 |
| type |
BINDING |
| sequence |
Y
|
| description |
BINDING => ECO:0007744|PDB:4EY5
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
B |
| residue |
122 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0007744|PDB:4BDT
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
6)
|
chain |
B |
| residue |
203 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0007744|PDB:4BDT
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
7)
|
chain |
B |
| residue |
439 |
| type |
BINDING |
| sequence |
W
|
| description |
BINDING => ECO:0007744|PDB:4BDT
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
8)
|
chain |
B |
| residue |
447 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0007744|PDB:4BDT
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
9)
|
chain |
B |
| residue |
203 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Acyl-ester intermediate
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
10)
|
chain |
B |
| residue |
334 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
11)
|
chain |
B |
| residue |
447 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
Charge relay system
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
12)
|
chain |
B |
| residue |
202 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0007744|PDB:4EY6
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
13)
|
chain |
B |
| residue |
350 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11053835, ECO:0000269|PubMed:20408548, ECO:0000269|PubMed:23035744, ECO:0000269|PubMed:23679855, ECO:0007744|PDB:1B41, ECO:0007744|PDB:1F8U, ECO:0007744|PDB:2X8B, ECO:0007744|PDB:4BDT, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7, ECO:0007744|PDB:4EY8
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
14)
|
chain |
B |
| residue |
464 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY8
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
|