eF-site ID 6ne5-D
PDB Code 6ne5
Chain D

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Title Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer
Classification APOPTOSIS
Compound Induced myeloid leukemia cell differentiation protein Mcl-1
Source (MCL1_HUMAN)
Sequence D:  DELYRQSLEIISRYLREQATGAKDTKPMSGATSRKALETL
RRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHV
FSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAES
ITDVLVRTKRDWLVKQRGWDGFVEFFHV
Description


Functional site

1) chain D
residue 227
type
sequence A
description binding site for residue KJP D 400
source : AC4

2) chain D
residue 228
type
sequence F
description binding site for residue KJP D 400
source : AC4

3) chain D
residue 231
type
sequence M
description binding site for residue KJP D 400
source : AC4

4) chain D
residue 246
type
sequence L
description binding site for residue KJP D 400
source : AC4

5) chain D
residue 250
type
sequence M
description binding site for residue KJP D 400
source : AC4

6) chain D
residue 253
type
sequence V
description binding site for residue KJP D 400
source : AC4

7) chain D
residue 254
type
sequence F
description binding site for residue KJP D 400
source : AC4

8) chain D
residue 258
type
sequence V
description binding site for residue KJP D 400
source : AC4

9) chain D
residue 260
type
sequence N
description binding site for residue KJP D 400
source : AC4

10) chain D
residue 262
type
sequence G
description binding site for residue KJP D 400
source : AC4

11) chain D
residue 263
type
sequence R
description binding site for residue KJP D 400
source : AC4

12) chain D
residue 267
type
sequence L
description binding site for residue KJP D 400
source : AC4

13) chain D
residue 270
type
sequence F
description binding site for residue KJP D 400
source : AC4

14) chain D
residue 271
type
sequence G
description binding site for residue KJP D 400
source : AC4

15) chain D
residue 294
type
sequence I
description binding site for residue KJP D 400
source : AC4

16) chain D
residue 194
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1

17) chain D
residue 197
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1


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