eF-site ID 6ne5-D PDB Code 6ne5 Chain D click to enlarge Title Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer Classification APOPTOSIS Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source (MCL1_HUMAN) Sequence D:  DELYRQSLEIISRYLREQATGAKDTKPMSGATSRKALETL RRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHV FSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAES ITDVLVRTKRDWLVKQRGWDGFVEFFHV Description Functional site 1) chain D residue 227 type sequence A description binding site for residue KJP D 400 source : AC4 2) chain D residue 228 type sequence F description binding site for residue KJP D 400 source : AC4 3) chain D residue 231 type sequence M description binding site for residue KJP D 400 source : AC4 4) chain D residue 246 type sequence L description binding site for residue KJP D 400 source : AC4 5) chain D residue 250 type sequence M description binding site for residue KJP D 400 source : AC4 6) chain D residue 253 type sequence V description binding site for residue KJP D 400 source : AC4 7) chain D residue 254 type sequence F description binding site for residue KJP D 400 source : AC4 8) chain D residue 258 type sequence V description binding site for residue KJP D 400 source : AC4 9) chain D residue 260 type sequence N description binding site for residue KJP D 400 source : AC4 10) chain D residue 262 type sequence G description binding site for residue KJP D 400 source : AC4 11) chain D residue 263 type sequence R description binding site for residue KJP D 400 source : AC4 12) chain D residue 267 type sequence L description binding site for residue KJP D 400 source : AC4 13) chain D residue 270 type sequence F description binding site for residue KJP D 400 source : AC4 14) chain D residue 271 type sequence G description binding site for residue KJP D 400 source : AC4 15) chain D residue 294 type sequence I description binding site for residue KJP D 400 source : AC4 16) chain D residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 17) chain D residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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