eF-site ID 6ne5-C PDB Code 6ne5 Chain C click to enlarge Title Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer Classification APOPTOSIS Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source (MCL1_HUMAN) Sequence C:  DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALE TLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMI HVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLA ESITDVLVRTKRDWLVKQRGWDGFVEFFHV Description Functional site 1) chain C residue 320 type sequence H description binding site for residue KJP A 400 source : AC1 2) chain C residue 224 type sequence H description binding site for residue KJP C 400 source : AC3 3) chain C residue 227 type sequence A description binding site for residue KJP C 400 source : AC3 4) chain C residue 228 type sequence F description binding site for residue KJP C 400 source : AC3 5) chain C residue 231 type sequence M description binding site for residue KJP C 400 source : AC3 6) chain C residue 250 type sequence M description binding site for residue KJP C 400 source : AC3 7) chain C residue 253 type sequence V description binding site for residue KJP C 400 source : AC3 8) chain C residue 254 type sequence F description binding site for residue KJP C 400 source : AC3 9) chain C residue 256 type sequence D description binding site for residue KJP C 400 source : AC3 10) chain C residue 258 type sequence V description binding site for residue KJP C 400 source : AC3 11) chain C residue 260 type sequence N description binding site for residue KJP C 400 source : AC3 12) chain C residue 262 type sequence G description binding site for residue KJP C 400 source : AC3 13) chain C residue 263 type sequence R description binding site for residue KJP C 400 source : AC3 14) chain C residue 267 type sequence L description binding site for residue KJP C 400 source : AC3 15) chain C residue 270 type sequence F description binding site for residue KJP C 400 source : AC3 16) chain C residue 271 type sequence G description binding site for residue KJP C 400 source : AC3 17) chain C residue 294 type sequence I description binding site for residue KJP C 400 source : AC3 18) chain C residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 19) chain C residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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