eF-site ID 6ne5-C
PDB Code 6ne5
Chain C

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Title Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer
Classification APOPTOSIS
Compound Induced myeloid leukemia cell differentiation protein Mcl-1
Source (MCL1_HUMAN)
Sequence C:  DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALE
TLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMI
HVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLA
ESITDVLVRTKRDWLVKQRGWDGFVEFFHV
Description


Functional site

1) chain C
residue 320
type
sequence H
description binding site for residue KJP A 400
source : AC1

2) chain C
residue 224
type
sequence H
description binding site for residue KJP C 400
source : AC3

3) chain C
residue 227
type
sequence A
description binding site for residue KJP C 400
source : AC3

4) chain C
residue 228
type
sequence F
description binding site for residue KJP C 400
source : AC3

5) chain C
residue 231
type
sequence M
description binding site for residue KJP C 400
source : AC3

6) chain C
residue 250
type
sequence M
description binding site for residue KJP C 400
source : AC3

7) chain C
residue 253
type
sequence V
description binding site for residue KJP C 400
source : AC3

8) chain C
residue 254
type
sequence F
description binding site for residue KJP C 400
source : AC3

9) chain C
residue 256
type
sequence D
description binding site for residue KJP C 400
source : AC3

10) chain C
residue 258
type
sequence V
description binding site for residue KJP C 400
source : AC3

11) chain C
residue 260
type
sequence N
description binding site for residue KJP C 400
source : AC3

12) chain C
residue 262
type
sequence G
description binding site for residue KJP C 400
source : AC3

13) chain C
residue 263
type
sequence R
description binding site for residue KJP C 400
source : AC3

14) chain C
residue 267
type
sequence L
description binding site for residue KJP C 400
source : AC3

15) chain C
residue 270
type
sequence F
description binding site for residue KJP C 400
source : AC3

16) chain C
residue 271
type
sequence G
description binding site for residue KJP C 400
source : AC3

17) chain C
residue 294
type
sequence I
description binding site for residue KJP C 400
source : AC3

18) chain C
residue 194
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1

19) chain C
residue 197
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1


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