eF-site ID 6ne5-B PDB Code 6ne5 Chain B click to enlarge Title Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer Classification APOPTOSIS Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source (MCL1_HUMAN) Sequence B:  DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALE TLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMI HVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLA ESITDVLVRTKRDWLVKQRGWDGFVEFFHVE Description Functional site 1) chain B residue 227 type sequence A description binding site for residue KJP B 400 source : AC2 2) chain B residue 228 type sequence F description binding site for residue KJP B 400 source : AC2 3) chain B residue 231 type sequence M description binding site for residue KJP B 400 source : AC2 4) chain B residue 246 type sequence L description binding site for residue KJP B 400 source : AC2 5) chain B residue 250 type sequence M description binding site for residue KJP B 400 source : AC2 6) chain B residue 253 type sequence V description binding site for residue KJP B 400 source : AC2 7) chain B residue 254 type sequence F description binding site for residue KJP B 400 source : AC2 8) chain B residue 258 type sequence V description binding site for residue KJP B 400 source : AC2 9) chain B residue 260 type sequence N description binding site for residue KJP B 400 source : AC2 10) chain B residue 262 type sequence G description binding site for residue KJP B 400 source : AC2 11) chain B residue 263 type sequence R description binding site for residue KJP B 400 source : AC2 12) chain B residue 267 type sequence L description binding site for residue KJP B 400 source : AC2 13) chain B residue 270 type sequence F description binding site for residue KJP B 400 source : AC2 14) chain B residue 271 type sequence G description binding site for residue KJP B 400 source : AC2 15) chain B residue 294 type sequence I description binding site for residue KJP B 400 source : AC2 16) chain B residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 17) chain B residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1

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