eF-site ID 6ne5-A PDB Code 6ne5 Chain A click to enlarge Title Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors that Demonstrate in vivo Activity in Mouse Xenograft Models of Human Cancer Classification APOPTOSIS Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source (MCL1_HUMAN) Sequence A:  DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALE TLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMI HVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLA ESITDVLVRTKRDWLVKQRGWDGFVEFFHVE Description Functional site 1) chain A residue 224 type sequence H description binding site for residue KJP A 400 source : AC1 2) chain A residue 227 type sequence A description binding site for residue KJP A 400 source : AC1 3) chain A residue 228 type sequence F description binding site for residue KJP A 400 source : AC1 4) chain A residue 231 type sequence M description binding site for residue KJP A 400 source : AC1 5) chain A residue 249 type sequence V description binding site for residue KJP A 400 source : AC1 6) chain A residue 250 type sequence M description binding site for residue KJP A 400 source : AC1 7) chain A residue 253 type sequence V description binding site for residue KJP A 400 source : AC1 8) chain A residue 254 type sequence F description binding site for residue KJP A 400 source : AC1 9) chain A residue 256 type sequence D description binding site for residue KJP A 400 source : AC1 10) chain A residue 258 type sequence V description binding site for residue KJP A 400 source : AC1 11) chain A residue 260 type sequence N description binding site for residue KJP A 400 source : AC1 12) chain A residue 263 type sequence R description binding site for residue KJP A 400 source : AC1 13) chain A residue 267 type sequence L description binding site for residue KJP A 400 source : AC1 14) chain A residue 270 type sequence F description binding site for residue KJP A 400 source : AC1 15) chain A residue 271 type sequence G description binding site for residue KJP A 400 source : AC1 16) chain A residue 294 type sequence I description binding site for residue KJP A 400 source : AC1 17) chain A residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 18) chain A residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 19) chain A residue 253-272 type prosite sequence VFSDGVTNWGRIVTLISFGA description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA source prosite : PS01080 20) chain A residue 305-316 type prosite sequence WLVKQRGWDGFV description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV source prosite : PS01258 21) chain A residue 209-223 type prosite sequence ALETLRRVGDGVQRN description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN source prosite : PS01259

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