eF-site ID 6ncp-ABCDEF PDB Code 6ncp Chain A, B, C, D, E, F click to enlarge Title Crystal structure of HIV-1 broadly neutralizing antibody ACS202 Classification IMMUNE SYSTEM Compound ACS202 Fab heavy chain Source (6NCP) Sequence A:  QVQLVESGGGVVQPGGSLRLSCAASGFAFKDFGMHWVRQA PGKGLEWVAVIGGGHGQHQSYSESVKGRFAITRDNEKNKL YLHMDRLRTEDTAVYYCAKDRLGRPWNIGGRLVYYYYGMD VWGQGTTVTVSSASTKGPSVFPLAPSSKGTAALGCLVKDY FPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVP SSSLGTQTYICNVNHKPSNTKVDKKVEP B:  AIRMTQSPSSLSASVGDRVTITCQASQDIKKSLNWYRQKP GKAPELLIHDASILQTGVPSAFTASGSGTHFSFVINKLQP EDVGTYFCQEYENLQFTFGPGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRG C:  QVQLVESGGGVVQPGGSLRLSCAASGFAFKDFGMHWVRQA PGKGLEWVAVIGGGHGQHQSYSESVKGRFAITRDNEKNKL YLHMDRLRTEDTAVYYCAKDRLGRPWNIGGRLVYYYYGMD VWGQGTTVTVSSASTKGPSVFPLAPSSKGGTAALGCLVKD YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTV PSSSLGTQTYICNVNHKPSNTKVDKKVEP D:  AIRMTQSPSSLSASVGDRVTITCQASQDIKKSLNWYRQKP GKAPELLIHDASILQTGVPSAFTASGSGTHFSFVINKLQP EDVGTYFCQEYENLQFTFGPGTKVEIKRTVAAPSVFIFPP SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG LSSPVTKSFNRG E:  AVGIGAVFL F:  HHHHH Description Functional site 1) chain A residue 106 type sequence G description binding site for residue SO4 A 301 source : AC1 2) chain A residue 107 type sequence T description binding site for residue SO4 A 301 source : AC1 3) chain A residue 108 type sequence T description binding site for residue SO4 A 301 source : AC1 4) chain A residue 149 type sequence P description binding site for residue SO4 A 301 source : AC1 5) chain A residue 201 type sequence K description binding site for residue SO4 A 301 source : AC1 6) chain B residue 3 type sequence R description binding site for residue GLY B 301 source : AC2 7) chain B residue 24 type sequence Q description binding site for residue GLY B 301 source : AC2 8) chain B residue 26 type sequence S description binding site for residue GLY B 301 source : AC2 9) chain C residue 82 type sequence M description binding site for residue SO4 C 301 source : AC3 10) chain C residue 83 type sequence R description binding site for residue SO4 C 301 source : AC3 11) chain C residue 53 type sequence H description binding site for residue SO4 D 301 source : AC4 12) chain D residue 109 type sequence T description binding site for residue SO4 D 301 source : AC4 13) chain D residue 110 type sequence V description binding site for residue SO4 D 301 source : AC4 14) chain A residue 21-34 type prosite sequence SCAASGFAFKDFGM description DEHYDRATASE_SER_THR Serine/threonine dehydratases pyridoxal-phosphate attachment site. Scaas.GFAFKDFGM source prosite : PS00165 15) chain B residue 192-198 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290 16) chain A residue 194-200 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290

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