eF-site ID 6nc6-AB PDB Code 6nc6 Chain A, B click to enlarge Title Lipid II flippase MurJ, inward closed conformation Classification TRANSPORT PROTEIN Compound Lipid II flippase MurJ Source (MURJ_THEAB) Sequence A:  LFSSILFSIATFFSRILGLFRDVLFAKYFGVSYELDAYFI AIMFPFFLRKVFGEGAMSSAFVPLYSEKSGEEKDKFLSSV INGFSLIILALVILSYFFPELIINLFGAGSSHETKILAKK LLLITSPSIYFIFLWAISYSILNTNNKFFWPALTPSISNI TIIIGTFLSTKYGIISPTIGFLIGSILMFFSIIKSIIKHK YYFTIKHFPHFLKLFFPTFMTMVVSQINTVVDMNVVSFYD KGSISYLQYASRFYLLPYGLFAVSVSTVVLSKISNDRKNF NYHLNDALKTTLFFTIPSMVGLIFLSTPIIRFFYEHGAFT SKDTLITSKILIAYTLGLPFYGIYSTISRSYHAIKNTKTP FIAATIVSLSNIILDIIFGLKYGPIGVALATSIAGIIGVL YLLFSVKTFPIKDFLKISLNSLIMLFVIYLTDFTDNEFWF LIQILIGILVYLIFSSIFYRDLIRRF B:  SILFSIATFFSRILGLFRDVLFAKYFGVSYELDAYFIAIM FPFFLRKVFGEGAMSSAFVPLYSEKSGEEKDKFLSSVING FSLIILALVILSYFFPELIINLFGAGSSHETKILAKKLLL ITSPSIYFIFLWAISYSILNTNNKFFWPALTPSISNITII IGTFLSTKYGIISPTIGFLIGSILMFFSIIKSIIKHKYYF TIKHFPHFLKLFFPTFMTMVVSQINTVVDMNVVSFYDKGS ISYLQYASRFYLLPYGLFAVSVSTVVLSKISNDRKNFNYH LNDALKTTLFFTIPSMVGLIFLSTPIIRFFYEHGAFTSKD TLITSKILIAYTLGLPFYGIYSTISRSYHAIKNTKTPFIA ATIVSLSNIILDIIFGLKYGPIGVALATSIAGIIGVLYLL FSVKTFPIKDFLKISLNSLIMLFVIYLTDFTDNEFWFLIQ ILIGILVYLIFSSIFYRDLIR Description Functional site 1) chain A residue 235 type sequence D description binding site for residue NA A 501 source : AC1 2) chain A residue 374 type sequence N description binding site for residue NA A 501 source : AC1 3) chain A residue 378 type sequence D description binding site for residue NA A 501 source : AC1 4) chain A residue 390 type sequence V description binding site for residue NA A 501 source : AC1 5) chain A residue 393 type sequence A description binding site for residue NA A 501 source : AC1 6) chain A residue 394 type sequence T description binding site for residue NA A 501 source : AC1 7) chain A residue 41 type sequence Y description binding site for residue CL A 502 source : AC2 8) chain A residue 45 type sequence I description binding site for residue CL A 502 source : AC2 9) chain A residue 255 type sequence R description binding site for residue CL A 502 source : AC2 10) chain A residue 71 type sequence K description binding site for residue CL A 503 source : AC3 11) chain A residue 210 type sequence H description binding site for residue CL A 503 source : AC3 12) chain A residue 213 type sequence H description binding site for residue CL A 503 source : AC3 13) chain A residue 210 type sequence H description binding site for residue CL A 504 source : AC4 14) chain A residue 213 type sequence H description binding site for residue CL A 504 source : AC4 15) chain A residue 210 type sequence H description binding site for residue ZN A 505 source : AC5 16) chain A residue 213 type sequence H description binding site for residue ZN A 505 source : AC5 17) chain A residue 175 type sequence Y description binding site for residue OLB A 506 source : AC6 18) chain A residue 178 type sequence I description binding site for residue OLB A 506 source : AC6 19) chain A residue 179 type sequence S description binding site for residue OLB A 506 source : AC6 20) chain A residue 182 type sequence I description binding site for residue OLB A 506 source : AC6 21) chain A residue 183 type sequence G description binding site for residue OLB A 506 source : AC6 22) chain B residue 70 type sequence E description binding site for residue OLB A 506 source : AC6 23) chain B residue 41 type sequence Y description binding site for residue CL B 501 source : AC7 24) chain B residue 255 type sequence R description binding site for residue CL B 501 source : AC7 25) chain B residue 71 type sequence K description binding site for residue CL B 502 source : AC8 26) chain B residue 210 type sequence H description binding site for residue CL B 502 source : AC8 27) chain B residue 213 type sequence H description binding site for residue CL B 502 source : AC8 28) chain B residue 71 type sequence K description binding site for residue CL B 503 source : AC9 29) chain B residue 210 type sequence H description binding site for residue CL B 503 source : AC9 30) chain B residue 210 type sequence H description binding site for residue ZN B 504 source : AD1 31) chain B residue 213 type sequence H description binding site for residue ZN B 504 source : AD1 32) chain B residue 57-78 type TOPO_DOM sequence EGAMSSAFVPLYSEKSGEEKDK description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 145-150 type TOPO_DOM sequence LNTNNK description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 34) chain B residue 197-213 type TOPO_DOM sequence KSIIKHKYYFTIKHFPH description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 272-287 type TOPO_DOM sequence VLSKISNDRKNFNYHL description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 354-362 type TOPO_DOM sequence YHAIKNTKT description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 408-416 type TOPO_DOM sequence SVKTFPIKD description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 57-78 type TOPO_DOM sequence EGAMSSAFVPLYSEKSGEEKDK description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 39) chain A residue 145-150 type TOPO_DOM sequence LNTNNK description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 197-213 type TOPO_DOM sequence KSIIKHKYYFTIKHFPH description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 272-287 type TOPO_DOM sequence VLSKISNDRKNFNYHL description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 42) chain A residue 354-362 type TOPO_DOM sequence YHAIKNTKT description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 43) chain A residue 408-416 type TOPO_DOM sequence SVKTFPIKD description Cytoplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI1 44) chain A residue 333-353 type TRANSMEM sequence ILIAYTLGLPFYGIYSTISRS description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 45) chain A residue 363-383 type TRANSMEM sequence PFIAATIVSLSNIILDIIFGL description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 387-407 type TRANSMEM sequence PIGVALATSIAGIIGVLYLLF description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 417-437 type TRANSMEM sequence FLKISLNSLIMLFVIYLTDFT description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 48) chain A residue 441-461 type TRANSMEM sequence FWFLIQILIGILVYLIFSSIF description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 49) chain B residue 36-56 type TRANSMEM sequence YELDAYFIAIMFPFFLRKVFG description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 79-99 type TRANSMEM sequence FLSSVINGFSLIILALVILSY description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 124-144 type TRANSMEM sequence LLLITSPSIYFIFLWAISYSI description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 151-171 type TRANSMEM sequence FFWPALTPSISNITIIIGTFL description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 53) chain A residue 36-56 type TRANSMEM sequence YELDAYFIAIMFPFFLRKVFG description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 176-196 type TRANSMEM sequence GIISPTIGFLIGSILMFFSII description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 214-238 type TRANSMEM sequence FLKLFFPTFMTMVVSQINTVVDMNV description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 250-271 type TRANSMEM sequence LQYASRFYLLPYGLFAVSVSTV description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 288-308 type TRANSMEM sequence NDALKTTLFFTIPSMVGLIFL description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 333-353 type TRANSMEM sequence ILIAYTLGLPFYGIYSTISRS description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 363-383 type TRANSMEM sequence PFIAATIVSLSNIILDIIFGL description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 60) chain B residue 387-407 type TRANSMEM sequence PIGVALATSIAGIIGVLYLLF description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 61) chain B residue 417-437 type TRANSMEM sequence FLKISLNSLIMLFVIYLTDFT description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 62) chain B residue 441-461 type TRANSMEM sequence FWFLIQILIGILVYLIFSSIF description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 63) chain A residue 79-99 type TRANSMEM sequence FLSSVINGFSLIILALVILSY description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 124-144 type TRANSMEM sequence LLLITSPSIYFIFLWAISYSI description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 65) chain A residue 151-171 type TRANSMEM sequence FFWPALTPSISNITIIIGTFL description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 66) chain A residue 176-196 type TRANSMEM sequence GIISPTIGFLIGSILMFFSII description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 214-238 type TRANSMEM sequence FLKLFFPTFMTMVVSQINTVVDMNV description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 250-271 type TRANSMEM sequence LQYASRFYLLPYGLFAVSVSTV description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 288-308 type TRANSMEM sequence NDALKTTLFFTIPSMVGLIFL description Helical => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI2 70) chain A residue 24-35 type TOPO_DOM sequence RDVLFAKYFGVS description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 71) chain B residue 172-175 type TOPO_DOM sequence STKY description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 72) chain B residue 239-249 type TOPO_DOM sequence VSFYDKGSISY description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 73) chain B residue 309-332 type TOPO_DOM sequence STPIIRFFYEHGAFTSKDTLITSK description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 74) chain B residue 384-386 type TOPO_DOM sequence KYG description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 75) chain B residue 438-440 type TOPO_DOM sequence DNE description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 76) chain A residue 100-123 type TOPO_DOM sequence FFPELIINLFGAGSSHETKILAKK description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 77) chain A residue 172-175 type TOPO_DOM sequence STKY description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 78) chain A residue 239-249 type TOPO_DOM sequence VSFYDKGSISY description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 79) chain A residue 309-332 type TOPO_DOM sequence STPIIRFFYEHGAFTSKDTLITSK description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 80) chain A residue 384-386 type TOPO_DOM sequence KYG description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 81) chain A residue 438-440 type TOPO_DOM sequence DNE description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 82) chain B residue 24-35 type TOPO_DOM sequence RDVLFAKYFGVS description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3 83) chain B residue 100-123 type TOPO_DOM sequence FFPELIINLFGAGSSHETKILAKK description Periplasmic => ECO:0000269|PubMed:28024149 source Swiss-Prot : SWS_FT_FI3

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