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eF-site ID
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6nbh-A |
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PDB Code
|
6nbh |
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Chain
|
A |
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click to enlarge
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Title
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Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein |
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Classification
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SIGNALING PROTEIN |
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Compound
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Parathyroid hormone/parathyroid hormone-related peptide receptor |
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Source
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(6NBH) |
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Sequence
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A: |
DQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGE
SGKSTIVKQTGIFETKFQVDKVNFHMFDVGGQRDERRKWI
QCFNDVTAIIFVVASSQTNRLQEALNLFKSIWNNRWLRTI
SVILFLNKQDLLAEKVLAIEDYFPEFARYTTPEDATPEPG
EDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDT
ENIRRVFNDCRDIIQRMHLRQYELL
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Description
|
(1) |
Parathyroid hormone/parathyroid hormone-related peptide receptor, Long-acting parathyroid hormone analog, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Nanobody-35
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Functional site
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|
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1)
|
chain |
A |
| residue |
47 |
| type |
BINDING |
| sequence |
G
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| description |
BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
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| source |
Swiss-Prot : SWS_FT_FI1
|
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2)
|
chain |
A |
| residue |
223 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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3)
|
chain |
A |
| residue |
292 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
366 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000305|PubMed:10427002, ECO:0000305|PubMed:11087399, ECO:0000305|PubMed:15591060, ECO:0000305|PubMed:16766715, ECO:0000305|PubMed:19243146, ECO:0000305|PubMed:9395396, ECO:0000305|PubMed:9417641
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
A |
| residue |
54 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10427002, ECO:0000269|PubMed:11087399, ECO:0000269|PubMed:15591060, ECO:0000269|PubMed:19243146, ECO:0000269|PubMed:9395396, ECO:0000269|PubMed:9417641, ECO:0000305|PubMed:16766715
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| source |
Swiss-Prot : SWS_FT_FI2
|
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6)
|
chain |
A |
| residue |
352 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000250|UniProtKB:P63092
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
7)
|
chain |
A |
| residue |
300 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P63092
|
| source |
Swiss-Prot : SWS_FT_FI6
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