eF-site ID 6nbd_1-C PDB Code 6nbd Model 1 Chain C click to enlarge Title Human methemoglobin state 2 determined using single-particle cryo-EM at 200 keV Classification OXYGEN TRANSPORT Compound Hemoglobin subunit alpha Source ORGANISM_COMMON: Human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence C:  VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTK TYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNAL SALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPA VHASLDKFLASVSTVLTSKY Description Functional site 1) chain C residue 42 type sequence Y description binding site for residue HEM C 201 source : AC3 2) chain C residue 43 type sequence F description binding site for residue HEM C 201 source : AC3 3) chain C residue 45 type sequence H description binding site for residue HEM C 201 source : AC3 4) chain C residue 46 type sequence F description binding site for residue HEM C 201 source : AC3 5) chain C residue 58 type sequence H description binding site for residue HEM C 201 source : AC3 6) chain C residue 61 type sequence K description binding site for residue HEM C 201 source : AC3 7) chain C residue 83 type sequence L description binding site for residue HEM C 201 source : AC3 8) chain C residue 86 type sequence L description binding site for residue HEM C 201 source : AC3 9) chain C residue 87 type sequence H description binding site for residue HEM C 201 source : AC3 10) chain C residue 91 type sequence L description binding site for residue HEM C 201 source : AC3 11) chain C residue 97 type sequence N description binding site for residue HEM C 201 source : AC3 12) chain C residue 98 type sequence F description binding site for residue HEM C 201 source : AC3 13) chain C residue 101 type sequence L description binding site for residue HEM C 201 source : AC3 14) chain C residue 132 type sequence V description binding site for residue HEM C 201 source : AC3 15) chain C residue 136 type sequence L description binding site for residue HEM C 201 source : AC3 16) chain C residue 61 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733 source Swiss-Prot : SWS_FT_FI13 17) chain C residue 8 type BINDING sequence T description proximal binding residue source Swiss-Prot : SWS_FT_FI3 18) chain C residue 13 type BINDING sequence A description proximal binding residue source Swiss-Prot : SWS_FT_FI3 19) chain C residue 24 type BINDING sequence Y description proximal binding residue source Swiss-Prot : SWS_FT_FI3 20) chain C residue 29 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 21) chain C residue 45 type BINDING sequence H description proximal binding residue source Swiss-Prot : SWS_FT_FI3 22) chain C residue 47 type BINDING sequence D description proximal binding residue source Swiss-Prot : SWS_FT_FI3 23) chain C residue 52 type BINDING sequence S description proximal binding residue source Swiss-Prot : SWS_FT_FI3 24) chain C residue 55 type BINDING sequence V description proximal binding residue source Swiss-Prot : SWS_FT_FI3 25) chain C residue 59 type BINDING sequence G description proximal binding residue source Swiss-Prot : SWS_FT_FI3 26) chain C residue 91 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 27) chain C residue 106 type BINDING sequence L description proximal binding residue source Swiss-Prot : SWS_FT_FI3 28) chain C residue 108 type BINDING sequence T description proximal binding residue source Swiss-Prot : SWS_FT_FI3 29) chain C residue 121 type BINDING sequence V description proximal binding residue source Swiss-Prot : SWS_FT_FI3 30) chain C residue 133 type BINDING sequence S description proximal binding residue source Swiss-Prot : SWS_FT_FI3 31) chain C residue 7 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 32) chain C residue 16 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 33) chain C residue 40 type MOD_RES sequence K description N-pyruvate 2-iminyl-valine; in Hb A1b source Swiss-Prot : SWS_FT_FI6 34) chain C residue 131 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 35) chain C residue 138 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 36) chain C residue 102 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 37) chain C residue 124 type MOD_RES sequence S description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411 source Swiss-Prot : SWS_FT_FI10 38) chain C residue 108 type CARBOHYD sequence T description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI11 39) chain C residue 134 type CARBOHYD sequence T description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI11 40) chain C residue 137 type CARBOHYD sequence T description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569 source Swiss-Prot : SWS_FT_FI11

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