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Title
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MERS-CoV S complex with human neutralizing LCA60 antibody Fab fragment (state 2) |
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Classification
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VIRUS |
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Compound
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Spike glycoprotein |
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Source
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(6NB4) |
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Sequence
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A: |
TVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGII
YPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTP
QKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTS
ATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCG
TLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDG
NYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGIT
QTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIP
HSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAI
DCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQ
AEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSL
FSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLS
VSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKY
SYINKCSRLLSDDRTEVPQLVNANQYSPCVSIVPSTVWED
GDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQY
GTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVF
QNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSV
PVSVIYDKETKTHATLFGSVACEHISSTMSQYSRYGPLQT
PVGCVLGLVNSSLFVEDCKLPLGQSLCALPDTPPGEMRLA
SIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQEYIQTTIQ
KVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANL
RQDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSAR
SAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQ
YVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSF
AAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGA
MQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAI
SASIGDIIQRLDPPEQDAQIDRLINGRLTTLNAFVAQQLV
RSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFV
VNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAP
VNGYFIKTNEWSYTGSSFYAPEPITSLNTKYVAPQVTYQN
ISTNLPPPL
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| B: |
TVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGII
YPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTP
QKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTS
ATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCG
TLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDG
NYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGIT
QTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIP
HSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAI
DCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQ
AFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQ
RFVYDAYQNLVGYYSDDGNYYCLRACVSVPVSVIYDKETK
THATLFGSVACEHISSTMSQYSRYGPLQTPVGCVLGLVNS
SLFVEDCKLPLGQSLCALPDTPPGEMRLASIAFNHPIQVD
QLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYVC
NGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFA
SVKSSQSSPIIPGFGGDFNLTLLEPVSARSAIEDLLFDKV
TIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPL
MDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFY
RLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEA
FQKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRL
DPPEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQL
AKDKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMH
VGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNEW
SYTGSSFYAPEPITSLNTKYVAPQVTYQNISTNLPPPL
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| C: |
TVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGII
YPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTP
QKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTS
ATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCG
TLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDG
NYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGIT
QTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIP
HSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAI
DCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQ
AEGANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQ
QRFVYDAYQNLVGYYSDDGNYYCLRACVSVPVSVIYDKET
KTHATLFGSVACEHISSTMSQYSRYGPLQTPVGCVLGLVN
SSLFVEDCKLPLGQSLCALPDTPPGEMRLASIAFNHPIQV
DQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYV
CNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLF
ASVKSSQSSPIIPGFGGDFNLTLLEPVSARSAIEDLLFDK
VTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPP
LMDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIF
YRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNE
AFQKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQR
LDPPEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQ
LAKDKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFM
HVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNE
WSYTGSSFYAPEPITSLNTKYVAPQVTYQNISTNLPPPL
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| H: |
VQLLESGGGLVKPGGSLRLSCEASGLTFSNVWMSWVRQAP
GKGLEWVGRIKRKSEGATTDYGAPVKGRFTLSRDDSKNTV
YLQMNSLKIDDTAVYYCSTLTRGGDVWSSSYYFDYWGQGA
LVT
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| L: |
ALTQPASVSGSPGQSITISCTGTSSDVGTYDLVSWYQQHP
GKSPKLMIYADIKRPSGVSHRFSGSKSGNTASLTISGLQS
ADEADYYCCLYAGSSTSVIFGGGTKV
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Description
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(1) |
Spike glycoprotein, LCA60 heavy chain, LCA60 light chain
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