eF-site ID 6n6j-A
PDB Code 6n6j
Chain A

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Title Human REXO2 bound to pAA
Classification rna binding protein/rna
Compound RNA exonuclease 2 homolog,Small fragment nuclease
Source (6N6J)
Sequence A:  GESMAQRMVWVDLEMTGLDIEKDQIIEMACLITDSDLNIL
AEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTI
TLQQAEYEFLSFVRQQTPPGLCPLAGNSVHEDKKFLDKYM
PQFMKHLHYRIIDVSTVKELCRRWYPEEYEFAPKKAASHR
ALDDISESIKELQFYRNNIFKKKIDEKKRKIIENG
Description


Functional site

1) chain A
residue 110
type
sequence N
description binding site for residue GOL A 301
source : AC1

2) chain A
residue 158
type
sequence K
description binding site for residue GOL A 301
source : AC1

3) chain A
residue 160
type
sequence A
description binding site for residue GOL A 301
source : AC1

4) chain A
residue 162
type
sequence H
description binding site for residue GOL A 301
source : AC1

5) chain A
residue 167
type
sequence D
description binding site for residue GOL A 301
source : AC1

6) chain A
residue 186
type
sequence K
description binding site for residue MLI A 302
source : AC2

7) chain A
residue 187
type
sequence I
description binding site for residue MLI A 302
source : AC2

8) chain A
residue 15
type
sequence D
description binding site for residue NA D 701
source : AC3

9) chain A
residue 86
type
sequence Q
description binding site for residue GOL B 301
source : AC4

10) chain A
residue 89
type
sequence E
description binding site for residue GOL B 301
source : AC4

11) chain A
residue 124
type
sequence P
description binding site for residue GOL B 301
source : AC4

12) chain A
residue 125
type
sequence Q
description binding site for residue GOL B 301
source : AC4

13) chain A
residue 53
type SITE
sequence Q
description Important for dinucleotide binding => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:32365187
source Swiss-Prot : SWS_FT_FI5

14) chain A
residue 96
type SITE
sequence V
description Important for dinucleotide binding => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:32365187
source Swiss-Prot : SWS_FT_FI5

15) chain A
residue 164
type SITE
sequence A
description Important for dinucleotide binding => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:32365187
source Swiss-Prot : SWS_FT_FI5

16) chain A
residue 92
type MOD_RES
sequence F
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI6

17) chain A
residue 122
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:15592455
source Swiss-Prot : SWS_FT_FI7

18) chain A
residue 47
type BINDING
sequence P
description BINDING => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0007744|PDB:6J7Y, ECO:0007744|PDB:6RCN
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 49
type BINDING
sequence L
description BINDING => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0007744|PDB:6J7Y, ECO:0007744|PDB:6RCN
source Swiss-Prot : SWS_FT_FI2

20) chain A
residue 194
type ACT_SITE
sequence I
description ACT_SITE => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 173
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:Q9D8S4
source Swiss-Prot : SWS_FT_FI8

22) chain A
residue 147
type BINDING
sequence W
description BINDING => ECO:0000269|PubMed:30926754, ECO:0000269|PubMed:31588022, ECO:0007744|PDB:6RCN
source Swiss-Prot : SWS_FT_FI3


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