eF-site ID 6n61-ABCDEFI PDB Code 6n61 Chain A, B, C, D, E, F, I click to enlarge Title Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin Classification TRANSFERASE/DNA Compound DNA-directed RNA polymerase subunit alpha Source (A0A096YQF1_BURTA) Sequence A:  FLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRRIL LSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNLKG LAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVKPQ HVICHLTDENASISMRIKVQRGRGYVPASTRIHSEEDERP IGRLLVDACYSPVERIAYNVEAARVEQRTDLDKLVIEMET NGTIDPEEAIRRAATILAEQLEAFVDLE B:  TEFLKPRLVDIEQVSSTHAKVTLEPLERGFGHTLGNALRR ILLSSMPGCAVTEVEIDGVLHEYSTKEGVQEDILEILLNL KGLAVRVQGKDEVILTLNKSGIGPVTAADITHDGDVEIVK PQHVICHLTDENASISMRIKVQRGRGYVPASTRLLVDACY SPVERIAYNVEAARVEQRTDLDKLVIEMETNGTIDPEEAI RRAATILAEQLEAFVDL C:  VYSYTEKKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQ DPEGQYGLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFD VQECQIRGVTYSAPLRVKLRLVIYEREGTVKDIKEQEVYM GEIPLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKT HSSGKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKL PATIILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPE RLRGETASFDIYVEKGRRITARHIRQLEKDDVKLIEVPVE YIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQSGH KRIETLFTNDLDHGPYISETLRVDPTNDRLSALVEIYRMM RPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNRSLL REEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDHLGN RRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTLMPQ DMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHKRRI SALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIG LINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLSAIE EGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSRDQV DYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQRQAV PTLRADKPLVGTGMERAVAVDSGVTAVAKRGGVVQYVDAS RIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQMPC VSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPWNGY NFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGPEEI TADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKVTPK GETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGTVID VQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQILEAG LFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEKQNQ LEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVLKIV KVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPYDEN GTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDKINA MLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDEEVM RLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTSGQI RLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARSTGS YSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEM LTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLLKEI RSLGINIELEDE D:  FDAIKIALASPDMIRSWSFGEVKKPETINYRTFKPERDGL FCARIFGPVKDYECLCGKYKRLKHRGVICEKCGVEVTQTK VRRERMGHIELASPTAHIWFLKSLPSRIGLLLDMPLRDIE RVLYFESYVVIEGGMTNLERQQILTEEQYLDALEEFGDEF DAKMGAEAIQALLKSMDLEQECEQLREELNETNSETKRKK LTKRIKLLEAFVQSGNKPEWMILTVLPVLPPDLRPLVPLD GGRFATSDLNDLYRRVINRNNRLKRLLDLAAPDIIVRNEK RMLQEAVDALLDNGRRGRAITGSNKRPLKSLADMIKGKQG RFRQNLLGKRVDYSGRSVITVGPYLRLHQCGLPKKMALEL FKPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVI REHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAA YNADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANG EPIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERL YRSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGR AILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKP TVIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISE AEAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKA MMDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQ IRQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFIST HGARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGT HEGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADI LVPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCA HCYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRTFH IGSSIQVKNKGSIKLSNVKSVVNSSGKLVITSRNTELKLI DEFGRTKESYKVPYGAVLAKGDGEQVAGGETVANWDPHTM ITGGLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKR RLVITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDG PEAPHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHI EVIVRQMLRKATIVNAGSSDGEQVEYSRVKIANRELEANG KVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAA VAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAA E:  ARVTVQDAVEKIGNRFDLVLVAARRARQMQVGGKDPLVPE ENDKTTVIALREIEEGLINNQILDVRERQEQQEQEAAEL F:  TTDPVRMYMREMGTVELLTREGEIDIAKRIEDGINQVQCS VAEVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQCKMP KKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVH RALQKLQQIEEETGLTIEQVKDINRRMSIGEAKARRAKKE MVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKAVDK FEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIE TINKLNRISRQMLQEMGREPTPEELAERMLMPEDKIRKVL KIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSATTE SLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGK QFDVTRERIRQIEAKALRKLRHPSRSEVLRSFLDD I:  GTPGFQTPDARVISRFG Description Functional site 1) chain C residue 139 type sequence N description binding site for residue EDO C 1401 source : AC1 2) chain C residue 140 type sequence G description binding site for residue EDO C 1401 source : AC1 3) chain C residue 141 type sequence T description binding site for residue EDO C 1401 source : AC1 4) chain C residue 758 type sequence R description binding site for residue EDO C 1401 source : AC1 5) chain C residue 1051 type sequence K description binding site for residue EDO C 1401 source : AC1 6) chain D residue 460 type sequence D description binding site for residue MG D 1501 source : AC2 7) chain D residue 462 type sequence D description binding site for residue MG D 1501 source : AC2 8) chain D residue 464 type sequence D description binding site for residue MG D 1501 source : AC2 9) chain D residue 70 type sequence C description binding site for residue ZN D 1502 source : AC3 10) chain D residue 72 type sequence C description binding site for residue ZN D 1502 source : AC3 11) chain D residue 85 type sequence C description binding site for residue ZN D 1502 source : AC3 12) chain D residue 87 type sequence K description binding site for residue ZN D 1502 source : AC3 13) chain D residue 88 type sequence C description binding site for residue ZN D 1502 source : AC3 14) chain D residue 814 type sequence C description binding site for residue ZN D 1503 source : AC4 15) chain D residue 888 type sequence C description binding site for residue ZN D 1503 source : AC4 16) chain D residue 895 type sequence C description binding site for residue ZN D 1503 source : AC4 17) chain D residue 898 type sequence C description binding site for residue ZN D 1503 source : AC4 18) chain D residue 511 type sequence Y description binding site for residue EPE D 1504 source : AC5 19) chain D residue 594 type sequence Q description binding site for residue EPE D 1504 source : AC5 20) chain D residue 595 type sequence A description binding site for residue EPE D 1504 source : AC5 21) chain D residue 596 type sequence L description binding site for residue EPE D 1504 source : AC5 22) chain D residue 597 type sequence G description binding site for residue EPE D 1504 source : AC5 23) chain D residue 600 type sequence A description binding site for residue EPE D 1504 source : AC5 24) chain D residue 727 type sequence D description binding site for residue EPE D 1504 source : AC5 25) chain F residue 403-416 type prosite sequence DLIQEGNIGLMKAV description SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnIGLMkAV source prosite : PS00715 26) chain C residue 1063-1075 type prosite sequence GDKMAGRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGV source prosite : PS01166 27) chain F residue 572-598 type prosite sequence TLEEVGKQFDVTRERIRQIEAKALRKL description SIGMA70_2 Sigma-70 factors family signature 2. TleEVGkqfdVTrerIrQIEakaLrkL source prosite : PS00716 28) chain D residue 895 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 29) chain D residue 898 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 30) chain D residue 460 type BINDING sequence D description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 31) chain D residue 462 type BINDING sequence D description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 32) chain D residue 464 type BINDING sequence D description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 33) chain D residue 814 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 34) chain D residue 888 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 35) chain D residue 70 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 36) chain D residue 72 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 37) chain D residue 85 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 38) chain D residue 88 type BINDING sequence C description BINDING => ECO:0000269|PubMed:32871103, ECO:0007744|PDB:4MEX, ECO:0007744|PDB:4MEY source Swiss-Prot : SWS_FT_FI1 39) chain D residue 983 type MOD_RES sequence K description N6-acetyllysine => ECO:0000255|HAMAP-Rule:MF_01322, ECO:0000269|PubMed:18723842 source Swiss-Prot : SWS_FT_FI2

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