eF-site ID 6n48-AB PDB Code 6n48 Chain A, B click to enlarge Title Structure of beta2 adrenergic receptor bound to BI167107, Nanobody 6B9, and a positive allosteric modulator Classification SIGNALING PROTEIN Compound Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera Source (6N48) Sequence A:  DAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHL LTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVD AAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVA GFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITT FRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITA IAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTK TWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITS PFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRAT HQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVF VYSRVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLP FFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCR SPDFRIAFQELLCL B:  QVQLQESGGGLVQAGGSLRLSCAASGSIFALNIMGWYRQA PGKQRELVAAIHSGGTTNYANSVKGRFTISRDNAANTVYL QMNSLKPEDTAVYYCNVKDFGAIIYDYDYWGQGTQVTVSS Description Functional site 1) chain A residue 1109 type sequence W description binding site for residue P0G A 1401 source : AC1 2) chain A residue 1113 type sequence D description binding site for residue P0G A 1401 source : AC1 3) chain A residue 1114 type sequence V description binding site for residue P0G A 1401 source : AC1 4) chain A residue 1191 type sequence C description binding site for residue P0G A 1401 source : AC1 5) chain A residue 1193 type sequence F description binding site for residue P0G A 1401 source : AC1 6) chain A residue 1200 type sequence A description binding site for residue P0G A 1401 source : AC1 7) chain A residue 1203 type sequence S description binding site for residue P0G A 1401 source : AC1 8) chain A residue 1207 type sequence S description binding site for residue P0G A 1401 source : AC1 9) chain A residue 1289 type sequence F description binding site for residue P0G A 1401 source : AC1 10) chain A residue 1293 type sequence N description binding site for residue P0G A 1401 source : AC1 11) chain A residue 1308 type sequence Y description binding site for residue P0G A 1401 source : AC1 12) chain A residue 1309 type sequence I description binding site for residue P0G A 1401 source : AC1 13) chain A residue 1312 type sequence N description binding site for residue P0G A 1401 source : AC1 14) chain A residue 1316 type sequence Y description binding site for residue P0G A 1401 source : AC1 15) chain A residue 1036 type sequence M description binding site for residue 1WV A 1402 source : AC2 16) chain A residue 1040 type sequence M description binding site for residue 1WV A 1402 source : AC2 17) chain A residue 1043 type sequence I description binding site for residue 1WV A 1402 source : AC2 18) chain A residue 1126 type sequence V description binding site for residue KBY A 1403 source : AC3 19) chain A residue 1130 type sequence D description binding site for residue KBY A 1403 source : AC3 20) chain A residue 1133 type sequence F description binding site for residue KBY A 1403 source : AC3 21) chain A residue 1137 type sequence S description binding site for residue KBY A 1403 source : AC3 22) chain A residue 1144 type sequence L description binding site for residue KBY A 1403 source : AC3 23) chain A residue 1145 type sequence L description binding site for residue KBY A 1403 source : AC3 24) chain A residue 1149 type sequence K description binding site for residue KBY A 1403 source : AC3 25) chain A residue 1153 type sequence I description binding site for residue KBY A 1403 source : AC3 26) chain A residue 1035-1058 type TRANSMEM sequence GMGIVMSLIVLAIVFGNVLVITAI description Helical; Name=1 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 1059-1071 type TOPO_DOM sequence AKFERLQTVTNYF description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 28) chain A residue 1130-1150 type TOPO_DOM sequence DRYFAITSPFKYQSLLTKNKA description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 29) chain A residue 1221-1302 type TOPO_DOM sequence RVFQEAKRQLQKFALKEHKALKTLGIIMGTFTLCWLPFFI VNIVHVIQDNL description Cytoplasmic source Swiss-Prot : SWS_FT_FI2 30) chain A residue 1072-1095 type TRANSMEM sequence ITSLACADLVMGLAVVPFGAAHIL description Helical; Name=2 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 1096-1106 type TOPO_DOM sequence TKTWTFGNFWC description Extracellular source Swiss-Prot : SWS_FT_FI4 32) chain A residue 1175-1196 type TOPO_DOM sequence RATHQEAINCYAEETCCDFFTN description Extracellular source Swiss-Prot : SWS_FT_FI4 33) chain A residue 1299-1305 type TOPO_DOM sequence QDNLIRK description Extracellular source Swiss-Prot : SWS_FT_FI4 34) chain A residue 1107-1129 type TRANSMEM sequence EFWTSIDVLCVTASIETLCVIAV description Helical; Name=3 source Swiss-Prot : SWS_FT_FI5 35) chain A residue 1151-1174 type TRANSMEM sequence RVIILMVWIVSGLTSFLPIQMHWY description Helical; Name=4 source Swiss-Prot : SWS_FT_FI6 36) chain A residue 1197-1220 type TRANSMEM sequence QAYAIASSIVSFYVPLVIMVFVYS description Helical; Name=5 source Swiss-Prot : SWS_FT_FI7 37) chain A residue 1275-1298 type TRANSMEM sequence LGIIMGTFTLCWLPFFIVNIVHVI description Helical; Name=6 source Swiss-Prot : SWS_FT_FI8 38) chain A residue 1306-1329 type TRANSMEM sequence EVYILLNWIGYVNSGFNPLIYCRS description Helical; Name=7 source Swiss-Prot : SWS_FT_FI9 39) chain A residue 1113 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 40) chain A residue 1118 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 41) chain A residue 1293 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 42) chain A residue 1312 type BINDING sequence N description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 43) chain A residue 1316 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18547522, ECO:0007744|PDB:3D4S source Swiss-Prot : SWS_FT_FI10 44) chain A residue 1203 type BINDING sequence S description BINDING => ECO:0000269|PubMed:17952055, ECO:0000269|PubMed:17962520, ECO:0007744|PDB:2RH1 source Swiss-Prot : SWS_FT_FI11 45) chain A residue 1141 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000269|PubMed:8521811 source Swiss-Prot : SWS_FT_FI12 46) chain A residue 1119-1135 type prosite sequence ASIETLCVIAVDRYFAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAVDRYFaI source prosite : PS00237 47) chain A residue 1265 type LIPID sequence A description S-palmitoyl cysteine => ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI16 48) chain A residue 1341 type LIPID sequence C description S-palmitoyl cysteine => ECO:0000269|PubMed:17962520, ECO:0000269|PubMed:18547522, ECO:0000269|PubMed:2540197, ECO:0000269|PubMed:27481942 source Swiss-Prot : SWS_FT_FI17 49) chain A residue 1274 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:17525332 source Swiss-Prot : SWS_FT_FI13 50) chain A residue 1289 type MOD_RES sequence F description Phosphoserine; by PKA => ECO:0000255 source Swiss-Prot : SWS_FT_FI14 51) chain A residue 1290 type MOD_RES sequence F description Phosphoserine; by PKA => ECO:0000255 source Swiss-Prot : SWS_FT_FI14

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