eF-site ID 6mv9-A PDB Code 6mv9 Chain A click to enlarge Title X-ray crystal structure of Bacillus subtilis ribonucleotide reductase NrdE alpha subunit with TTP and ADP Classification OXIDOREDUCTASE Compound Ribonucleoside-diphosphate reductase Source (A0A162Q3J9_BACIU) Sequence A:  KWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQNTVF FHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAK KFRFPSFMSAFKFYNDYALKTNDKKKILERYEDRISIVAL FFANGDTEKAKEYVNLMINQEYQPSTPTFLNAGRKRRGEL VSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLR AKGEAIKDVENATKGVVGVMKLLDNAFRYADQMGQRQGSG AAYLNIFHRDINDFLDTKKISAVKTLSIGVVIPDKFVELA REDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRV KKEKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNH ISKVKFSNLCSEVLQASQVSSYTDYDEEDEIGLDISCNLG SLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPAVR RANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFF MMVNFYSIQRSAEIAKEKGETFDQYEGSTYATGEYFDKYV STDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVAEHGMYH SYRLCIAPTGSISYVQSSTASVMPIMERIEEKTYYPMPGL ASNNWFFYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFL KDTMTTRDLNRIDLYAHHRGIKTIYYASCLSCVV Description Functional site 1) chain A residue 177 type sequence D description binding site for residue TTP A 801 source : AC1 2) chain A residue 178 type sequence S description binding site for residue TTP A 801 source : AC1 3) chain A residue 179 type sequence L description binding site for residue TTP A 801 source : AC1 4) chain A residue 182 type sequence I description binding site for residue TTP A 801 source : AC1 5) chain A residue 207 type sequence R description binding site for residue TTP A 801 source : AC1 6) chain A residue 213 type sequence I description binding site for residue TTP A 801 source : AC1 7) chain A residue 214 type sequence K description binding site for residue TTP A 801 source : AC1 8) chain A residue 220 type sequence T description binding site for residue TTP A 801 source : AC1 9) chain A residue 221 type sequence K description binding site for residue TTP A 801 source : AC1 10) chain A residue 33 type sequence V description binding site for residue ADP A 802 source : AC2 11) chain A residue 34 type sequence H description binding site for residue ADP A 802 source : AC2 12) chain A residue 37 type sequence F description binding site for residue ADP A 802 source : AC2 13) chain A residue 42 type sequence N description binding site for residue ADP A 802 source : AC2 14) chain A residue 89 type sequence F description binding site for residue ADP A 802 source : AC2 15) chain A residue 90 type sequence R description binding site for residue ADP A 802 source : AC2 16) chain A residue 91 type sequence F description binding site for residue ADP A 802 source : AC2 17) chain A residue 194 type sequence K description binding site for residue TTP B 801 source : AC4 18) chain A residue 236 type sequence Y description binding site for residue TTP B 801 source : AC4 19) chain A residue 237 type sequence A description binding site for residue TTP B 801 source : AC4 20) chain A residue 380 type ACT_SITE sequence N description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 384 type ACT_SITE sequence E description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 382 type ACT_SITE sequence C description Cysteine radical intermediate => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 153 type BINDING sequence T description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 169 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 198 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 26) chain A residue 380 type BINDING sequence N description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 580 type BINDING sequence P description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 170 type SITE sequence C description Important for hydrogen atom transfer => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 29) chain A residue 409 type SITE sequence C description Important for hydrogen atom transfer => ECO:0000250 source Swiss-Prot : SWS_FT_FI4 30) chain A residue 695 type SITE sequence C description Interacts with thioredoxin/glutaredoxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 31) chain A residue 698 type SITE sequence C description Interacts with thioredoxin/glutaredoxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 32) chain A residue 177 type SITE sequence D description Allosteric effector binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 33) chain A residue 207 type SITE sequence R description Allosteric effector binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI5 34) chain A residue 683 type SITE sequence Y description Important for electron transfer => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 35) chain A residue 684 type SITE sequence Y description Important for electron transfer => ECO:0000250 source Swiss-Prot : SWS_FT_FI6 36) chain A residue 558-580 type prosite sequence WKKLKAFVAEHGMYHSYRLCIAP description RIBORED_LARGE Ribonucleotide reductase large subunit signature. WkkLkafvaehGMYHsyrLCiaP source prosite : PS00089

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