eF-site ID 6mtg-A PDB Code 6mtg Chain A click to enlarge Title A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure Classification TRANSFERASE Compound Homoserine O-succinyltransferase Source (METAS_ECOLI) Sequence A:  PIRVPDELPAVNFLREENVFVMTTSRAQEIRPLKVLILNL MPKKIETENQFLRLLSNSPLQVDIQLLRIDSRETPAEHLN NFYCNFEDIQDQNFDGLIVTGAPLGLVEFNDVAYWPQIKQ VLEWSKDHVTSTLFVXWAVQAALNILYGIPKQTRTEKLSG VYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYT DLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQE FFRDVEAGLDIDVPYNYFPHNDPQNTPRASWRSHGNLLFT NWLNYYVYQIH Description Functional site 1) chain A residue 82 type sequence A description binding site for residue PEG A 401 source : AC1 2) chain A residue 18 type sequence E description binding site for residue PEG A 402 source : AC2 3) chain A residue 20 type sequence V description binding site for residue PEG A 402 source : AC2 4) chain A residue 176 type sequence H description binding site for residue PEG A 402 source : AC2 5) chain A residue 181 type sequence R description binding site for residue PEG A 402 source : AC2 6) chain A residue 177 type sequence A description binding site for residue FMT A 403 source : AC3 7) chain A residue 178 type sequence L description binding site for residue FMT A 403 source : AC3 8) chain A residue 179 type sequence L description binding site for residue FMT A 403 source : AC3 9) chain A residue 292 type sequence Y description binding site for residue FMT A 403 source : AC3 10) chain A residue 255 type sequence L description binding site for residue FMT A 404 source : AC4 11) chain A residue 256 type sequence D description binding site for residue FMT A 404 source : AC4 12) chain A residue 158 type sequence Q description binding site for residue FMT B 404 source : AC8 13) chain A residue 142 type ACT_SITE sequence X description Acyl-thioester intermediate => ECO:0000255|HAMAP-Rule:MF_00295, ECO:0000305|PubMed:10572016, ECO:0000305|PubMed:17302437, ECO:0000305|PubMed:17442255 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 235 type ACT_SITE sequence H description Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00295, ECO:0000305|PubMed:17302437, ECO:0000305|PubMed:17442255 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 237 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00295, ECO:0000305|PubMed:17302437, ECO:0000305|PubMed:17442255 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 163 type BINDING sequence K description BINDING => ECO:0000255|HAMAP-Rule:MF_00295 source Swiss-Prot : SWS_FT_FI4 17) chain A residue 192 type BINDING sequence S description BINDING => ECO:0000255|HAMAP-Rule:MF_00295 source Swiss-Prot : SWS_FT_FI4 18) chain A residue 249 type BINDING sequence R description BINDING => ECO:0000255|HAMAP-Rule:MF_00295 source Swiss-Prot : SWS_FT_FI4 19) chain A residue 111 type SITE sequence G description Important for acyl-CoA specificity => ECO:0000255|HAMAP-Rule:MF_00295 source Swiss-Prot : SWS_FT_FI5 20) chain A residue 192 type SITE sequence S description Important for substrate specificity => ECO:0000255|HAMAP-Rule:MF_00295 source Swiss-Prot : SWS_FT_FI6

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