eF-site ID 6mso-B PDB Code 6mso Chain B click to enlarge Title Crystal structure of mitochondrial fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate Classification LYASE/LYASE inhibitor Compound fumarate hydratase Source (Q4QAU9_LEIMA) Sequence B:  AEFNFVPLVSKVSHKETKYRLLTKDYVSVVQPGAGLPEML RVDPAALTLLSSTAFDDVEHLLRSSHLMSLRKIFDDPEAS DNDKFVALQLLKNANISSARLLPGCQDTGTAIIAGYRGDQ VFVPGNDEEALSRGVYDIFQKRNFRYSQNVPLSMYDEKNT GTNLPAQIDLYASKGMEYSFMFVAKGGGSANKSFLLQETK SVLNPKSLRNFLKEKLAMFGTSACPPYHVAVVIGGTSAEM TMKVLKYASCHYYDDLITKPDMKTGYTFRDLELEEEVLKV CQNIGMGAQFGGKYYAHDVRVIRMPRHGASCPIGIGVSCS ADRQALGKINKDGVWLEELEMEPSQYLPDLKEDELLKTPA VMVNLNRPMPEVLQELSKHPVRTRLSLTGTIIVARDSAHA RMREMLEAGKPLPQYMKEHPVYYAGPAKQPDGLPSGSFGP TTAGRMDPFVDLFQSHGGSMVMLAKGNRSKQVTKACHKYG GFYLGSIGGPAAVLAQNAIKKVECLDMKDLGMEAVWRIEV ENFPAFIVVDDKGNDFFEQL Description Functional site 1) chain B residue 354 type sequence Q description binding site for residue 1PE A 609 source : AC9 2) chain B residue 355 type sequence Y description binding site for residue 1PE A 609 source : AC9 3) chain B residue 213 type sequence N description binding site for residue 1PE A 610 source : AD1 4) chain B residue 216 type sequence S description binding site for residue 1PE A 610 source : AD1 5) chain B residue 114 type sequence C description binding site for residue SF4 B 601 source : AD3 6) chain B residue 115 type sequence Q description binding site for residue SF4 B 601 source : AD3 7) chain B residue 195 type sequence G description binding site for residue SF4 B 601 source : AD3 8) chain B residue 233 type sequence C description binding site for residue SF4 B 601 source : AD3 9) chain B residue 328 type sequence C description binding site for residue SF4 B 601 source : AD3 10) chain B residue 330 type sequence A description binding site for residue SF4 B 601 source : AD3 11) chain B residue 474 type sequence K description binding site for residue SF4 B 601 source : AD3 12) chain B residue 23 type sequence H description binding site for residue GOL B 602 source : AD4 13) chain B residue 28 type sequence Y description binding site for residue GOL B 602 source : AD4 14) chain B residue 337 type sequence K description binding site for residue GOL B 602 source : AD4 15) chain B residue 520 type sequence G description binding site for residue GOL B 603 source : AD5 16) chain B residue 521 type sequence M description binding site for residue GOL B 603 source : AD5 17) chain B residue 115 type sequence Q description binding site for residue JYD B 604 source : AD6 18) chain B residue 116 type sequence D description binding site for residue JYD B 604 source : AD6 19) chain B residue 154 type sequence R description binding site for residue JYD B 604 source : AD6 20) chain B residue 196 type sequence G description binding site for residue JYD B 604 source : AD6 21) chain B residue 197 type sequence G description binding site for residue JYD B 604 source : AD6 22) chain B residue 404 type sequence R description binding site for residue JYD B 604 source : AD6 23) chain B residue 450 type sequence T description binding site for residue JYD B 604 source : AD6 24) chain B residue 451 type sequence T description binding site for residue JYD B 604 source : AD6 25) chain B residue 454 type sequence R description binding site for residue JYD B 604 source : AD6 26) chain B residue 474 type sequence K description binding site for residue JYD B 604 source : AD6 27) chain B residue 33 type sequence K description binding site for residue 1PE B 605 source : AD7 28) chain B residue 341 type sequence D description binding site for residue 1PE B 605 source : AD7 29) chain B residue 87 type sequence E description binding site for residue 1PE B 606 source : AD8 30) chain B residue 291 type sequence Q description binding site for residue 1PE B 606 source : AD8 31) chain B residue 302 type sequence K description binding site for residue 1PE B 606 source : AD8 32) chain B residue 487 type sequence K description binding site for residue 1PE D 603 source : AE8 33) chain B residue 488 type sequence Y description binding site for residue 1PE D 603 source : AE8 34) chain B residue 114 type BINDING sequence C description BINDING => ECO:0000269|PubMed:30645090, ECO:0007744|PDB:6MSO source Swiss-Prot : SWS_FT_FI1 35) chain B residue 233 type BINDING sequence C description BINDING => ECO:0000269|PubMed:30645090, ECO:0007744|PDB:6MSO source Swiss-Prot : SWS_FT_FI1 36) chain B residue 328 type BINDING sequence C description BINDING => ECO:0000269|PubMed:30645090, ECO:0007744|PDB:6MSO source Swiss-Prot : SWS_FT_FI1 37) chain B residue 197 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:E9AE57 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 200 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:E9AE57 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 404 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:E9AE57 source Swiss-Prot : SWS_FT_FI2 40) chain B residue 450 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:E9AE57 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 474 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:E9AE57 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 115 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:E9AE57 source Swiss-Prot : SWS_FT_FI2 43) chain B residue 154 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:E9AE57 source Swiss-Prot : SWS_FT_FI2

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