eF-site ID 6msn-A PDB Code 6msn Chain A click to enlarge Title Crystal structure of cytosolic fumarate hydratase from Leishmania major in a complex with inhibitor thiomalate Classification LYASE Compound fumarate hydratase Source (E9AE57_LEIMA) Sequence A:  DFHFSAIFQPTDPHHHQTEFAKVEGSEKYVEEVEVFGRQA LKVNPEALTILAHRAFSDVHHFFRKDHLEGWRRAIEDPEA SDNDRYVATTLLKNACIAAGRVLPSCQDTGTAIVLGKRGE LCWTGGEDEKYLSKGIWNAYRYHNLRYSQTAALDMFKECN TGDNLPAQLDLLAVPGSDYEFLFIAKGGGSANKAYLYQET KALLNPKSLRAFIEEKLKTLGTAACPPYHIALVIGGTSAE MTMKTVKLASCRYYDSLPTTGDKYGRAFRDPEWEKIVMEV AQKSGIGAQFGGKYFAHQARVIRLPRHGASCPVGLAVSCS ADRQILAHINKSGIYIEQLEQNPAQYLPTSVKVDLKRPID KVRQQLSQYPVGTRVMLNGTLIVARDIAHAKIKEMMDNGE PLPEYMKTSPIYYAGPAKTPEGYASGSFGPTTAGRMDSYV DLFQSHGGSYITLAKGNRSKQVTDACKKHGGFYLGSIGGP AAILAKDSIKQVTCLAFPELGMEAVWKIEVEDFPAFIVVD DKGNDMYSKTLA Description Functional site 1) chain A residue 133 type sequence C description binding site for residue SF4 A 601 source : AC1 2) chain A residue 134 type sequence Q description binding site for residue SF4 A 601 source : AC1 3) chain A residue 214 type sequence G description binding site for residue SF4 A 601 source : AC1 4) chain A residue 252 type sequence C description binding site for residue SF4 A 601 source : AC1 5) chain A residue 346 type sequence C description binding site for residue SF4 A 601 source : AC1 6) chain A residue 348 type sequence A description binding site for residue SF4 A 601 source : AC1 7) chain A residue 491 type sequence K description binding site for residue SF4 A 601 source : AC1 8) chain A residue 134 type sequence Q description binding site for residue JYD A 602 source : AC2 9) chain A residue 135 type sequence D description binding site for residue JYD A 602 source : AC2 10) chain A residue 173 type sequence R description binding site for residue JYD A 602 source : AC2 11) chain A residue 215 type sequence G description binding site for residue JYD A 602 source : AC2 12) chain A residue 216 type sequence G description binding site for residue JYD A 602 source : AC2 13) chain A residue 421 type sequence R description binding site for residue JYD A 602 source : AC2 14) chain A residue 467 type sequence T description binding site for residue JYD A 602 source : AC2 15) chain A residue 468 type sequence T description binding site for residue JYD A 602 source : AC2 16) chain A residue 471 type sequence R description binding site for residue JYD A 602 source : AC2 17) chain A residue 491 type sequence K description binding site for residue JYD A 602 source : AC2 18) chain A residue 491 type BINDING sequence K description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 19) chain A residue 346 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 20) chain A residue 421 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 21) chain A residue 467 type BINDING sequence T description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 22) chain A residue 133 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 23) chain A residue 134 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 24) chain A residue 173 type BINDING sequence R description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 25) chain A residue 216 type BINDING sequence G description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 26) chain A residue 219 type BINDING sequence N description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1 27) chain A residue 252 type BINDING sequence C description BINDING => ECO:0000269|PubMed:27528683, ECO:0007744|PDB:5L2R source Swiss-Prot : SWS_FT_FI1

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