|
|
eF-site ID
|
6msk-E |
|
PDB Code
|
6msk |
|
Chain
|
E |
|
click to enlarge
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Title
|
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome |
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Classification
|
HYDROLASE |
|
Compound
|
26S proteasome non-ATPase regulatory subunit 1 |
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Source
|
(PSB4_HUMAN) |
|
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Sequence
|
E: |
MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQY
EKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYV
VGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVY
NMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQ
RVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVS
SSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGG
RRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATN
RPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPI
TKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD
FVVQEDFMKAVRKVADSKKLESKLDYKPV
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|
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Description
|
(1) |
26S proteasome
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
273-291 |
| type |
prosite |
| sequence |
VKMIMATNRPDTLDPALLR
|
| description |
AAA AAA-protein family signature. IkVImATNridiLDsALl.R
|
| source |
prosite : PS00674
|
|
|
2)
|
chain |
E |
| residue |
174 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
E |
| residue |
72 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
E |
| residue |
206 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-acetyllysine => ECO:0007744|PubMed:19608861
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
E |
| residue |
244 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|