eF-site ID 6msh-E PDB Code 6msh Chain E click to enlarge Title Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome Classification HYDROLASE Compound 26S proteasome non-ATPase regulatory subunit 1 Source (PSB4_HUMAN) Sequence E:  MADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQY EKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYV VGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPLVY NMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQ RVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVS SSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGG RRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATN RPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPI TKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD FVVQEDFMKAVRKVADSKKLESKLDYKPV Description (1)  26S proteasome Functional site 1) chain E residue 291 type sequence R description binding site for residue ATP D 501 source : AC3 2) chain E residue 294 type sequence R description binding site for residue ATP D 501 source : AC3 3) chain E residue 134 type sequence E description binding site for residue ATP E 401 source : AC4 4) chain E residue 135 type sequence I description binding site for residue ATP E 401 source : AC4 5) chain E residue 136 type sequence G description binding site for residue ATP E 401 source : AC4 6) chain E residue 176 type sequence P description binding site for residue ATP E 401 source : AC4 7) chain E residue 177 type sequence G description binding site for residue ATP E 401 source : AC4 8) chain E residue 178 type sequence T description binding site for residue ATP E 401 source : AC4 9) chain E residue 179 type sequence G description binding site for residue ATP E 401 source : AC4 10) chain E residue 180 type sequence K description binding site for residue ATP E 401 source : AC4 11) chain E residue 181 type sequence T description binding site for residue ATP E 401 source : AC4 12) chain E residue 182 type sequence L description binding site for residue ATP E 401 source : AC4 13) chain E residue 312 type sequence I description binding site for residue ATP E 401 source : AC4 14) chain E residue 316 type sequence H description binding site for residue ATP E 401 source : AC4 15) chain E residue 340 type sequence G description binding site for residue ATP E 401 source : AC4 16) chain E residue 341 type sequence A description binding site for residue ATP E 401 source : AC4 17) chain E residue 344 type sequence R description binding site for residue ATP E 401 source : AC4 18) chain E residue 273-291 type prosite sequence VKMIMATNRPDTLDPALLR description AAA AAA-protein family signature. VkVImATNradtLDpALl.R source prosite : PS00674 19) chain E residue 174 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 20) chain E residue 72 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 21) chain E residue 206 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 22) chain E residue 244 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3

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