eF-site ID 6msg-A PDB Code 6msg Chain A click to enlarge Title Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome Classification HYDROLASE Compound 26S proteasome non-ATPase regulatory subunit 1 Source (PSB4_HUMAN) Sequence A:  ESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADS EDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNK YQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEK LREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCA RAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMART KKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQL DGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLP DLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIR SVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAK Description (1)  26S proteasome Functional site 1) chain A residue 176 type sequence D description binding site for residue ADP A 501 source : AC2 2) chain A residue 177 type sequence V description binding site for residue ADP A 501 source : AC2 3) chain A residue 178 type sequence G description binding site for residue ADP A 501 source : AC2 4) chain A residue 219 type sequence G description binding site for residue ADP A 501 source : AC2 5) chain A residue 220 type sequence T description binding site for residue ADP A 501 source : AC2 6) chain A residue 222 type sequence K description binding site for residue ADP A 501 source : AC2 7) chain A residue 223 type sequence T description binding site for residue ADP A 501 source : AC2 8) chain A residue 224 type sequence L description binding site for residue ADP A 501 source : AC2 9) chain A residue 353 type sequence H description binding site for residue ADP A 501 source : AC2 10) chain A residue 354 type sequence I description binding site for residue ADP A 501 source : AC2 11) chain A residue 358 type sequence H description binding site for residue ADP A 501 source : AC2 12) chain A residue 382 type sequence G description binding site for residue ADP A 501 source : AC2 13) chain A residue 315-333 type prosite sequence IKVLMATNRPDTLDPALMR description AAA AAA-protein family signature. IkVImATNridiLDsALl.R source prosite : PS00674

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