|
|
eF-site ID
|
6msd-i |
|
PDB Code
|
6msd |
|
Chain
|
i |
|
click to enlarge
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Title
|
Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome |
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Classification
|
HYDROLASE |
|
Compound
|
26S proteasome non-ATPase regulatory subunit 1 |
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Source
|
(PSB4_HUMAN) |
|
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Sequence
|
i: |
SRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILAND
GVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITS
DANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAY
TQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKA
TCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTM
DVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHE
EEEAKAEREK
|
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Description
|
(1) |
26S proteasome
|
|
Functional site
|
|
|
1)
|
chain |
i |
| residue |
127 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphoserine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
2)
|
chain |
i |
| residue |
176 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphoserine => ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
i |
| residue |
5-27 |
| type |
prosite |
| sequence |
YDSRTTIFSPEGRLYQVEYAMEA
|
| description |
PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YsfslTtFSPsGKlvQIEYAlaA
|
| source |
prosite : PS00388
|
|
|
4)
|
chain |
i |
| residue |
35-82 |
| type |
prosite |
| sequence |
LGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMAC
SVAGITSD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGVkFegGVVIAADmlgsygslarfrnis.RimrvnnstmlgasGdyAD
|
| source |
prosite : PS00854
|
|
|
|