eF-site ID 6mh1-B PDB Code 6mh1 Chain B click to enlarge Title CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH HU-10, A 1,4,5-Trisubstituted Imidazole Analogue Classification TRANSCRIPTION/TRANSCRIPTION INHIBITOR Compound Bromodomain-containing protein 4 Source (BRD4_HUMAN) Sequence B:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE Description Functional site 1) chain B residue 116 type sequence N description binding site for residue EDO A 202 source : AC2 2) chain B residue 81 type sequence W description binding site for residue JQP B 201 source : AC4 3) chain B residue 82 type sequence P description binding site for residue JQP B 201 source : AC4 4) chain B residue 83 type sequence F description binding site for residue JQP B 201 source : AC4 5) chain B residue 92 type sequence L description binding site for residue JQP B 201 source : AC4 6) chain B residue 97 type sequence Y description binding site for residue JQP B 201 source : AC4 7) chain B residue 132 type sequence M description binding site for residue JQP B 201 source : AC4 8) chain B residue 136 type sequence C description binding site for residue JQP B 201 source : AC4 9) chain B residue 140 type sequence N description binding site for residue JQP B 201 source : AC4 10) chain B residue 146 type sequence I description binding site for residue JQP B 201 source : AC4 11) chain B residue 100 type sequence I description binding site for residue EDO B 202 source : AC5 12) chain B residue 101 type sequence I description binding site for residue EDO B 202 source : AC5 13) chain B residue 102 type sequence K description binding site for residue EDO B 202 source : AC5 14) chain B residue 103 type sequence T description binding site for residue EDO B 202 source : AC5 15) chain B residue 135 type sequence N description binding site for residue EDO B 202 source : AC5 16) chain B residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 17) chain B residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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