eF-site ID 6mh1-A PDB Code 6mh1 Chain A click to enlarge Title CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH HU-10, A 1,4,5-Trisubstituted Imidazole Analogue Classification TRANSCRIPTION/TRANSCRIPTION INHIBITOR Compound Bromodomain-containing protein 4 Source (BRD4_HUMAN) Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE Description Functional site 1) chain A residue 81 type sequence W description binding site for residue JQP A 201 source : AC1 2) chain A residue 82 type sequence P description binding site for residue JQP A 201 source : AC1 3) chain A residue 83 type sequence F description binding site for residue JQP A 201 source : AC1 4) chain A residue 92 type sequence L description binding site for residue JQP A 201 source : AC1 5) chain A residue 97 type sequence Y description binding site for residue JQP A 201 source : AC1 6) chain A residue 132 type sequence M description binding site for residue JQP A 201 source : AC1 7) chain A residue 140 type sequence N description binding site for residue JQP A 201 source : AC1 8) chain A residue 100 type sequence I description binding site for residue EDO A 202 source : AC2 9) chain A residue 101 type sequence I description binding site for residue EDO A 202 source : AC2 10) chain A residue 102 type sequence K description binding site for residue EDO A 202 source : AC2 11) chain A residue 103 type sequence T description binding site for residue EDO A 202 source : AC2 12) chain A residue 135 type sequence N description binding site for residue EDO A 202 source : AC2 13) chain A residue 130 type sequence N description binding site for residue EDO A 203 source : AC3 14) chain A residue 134 type sequence T description binding site for residue EDO A 203 source : AC3 15) chain A residue 137 type sequence Y description binding site for residue EDO A 203 source : AC3 16) chain A residue 154 type sequence E description binding site for residue EDO A 203 source : AC3 17) chain A residue 145 type sequence D description binding site for residue JQP B 201 source : AC4 18) chain A residue 149 type sequence M description binding site for residue JQP B 201 source : AC4 19) chain A residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 80-139 type prosite sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY WNAQECIQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY source prosite : PS00633

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