eF-site ID 6md7-B PDB Code 6md7 Chain B click to enlarge Title Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Tyrosine-protein phosphatase non-receptor type 11 Source (PTN11_HUMAN) Sequence B:  RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTL SVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYME HHGQLKENGDVIELKYPLNCADPTSERWFHGHLSGKEAEK LLTEKGKHGSFLVRESQSHPGDFVLSVRTNDGKSKVTHVM IRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQ LKQPLNTTRINAAEIESRVRELSKQGFWEEFETLQQQECK LLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHVSDYINA NIIMPEPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMT TKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDY TLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVL DFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYM AVQHYIETL Description Functional site 1) chain B residue 108 type sequence T description binding site for residue JE1 B 601 source : AC8 2) chain B residue 110 type sequence E description binding site for residue JE1 B 601 source : AC8 3) chain B residue 111 type sequence R description binding site for residue JE1 B 601 source : AC8 4) chain B residue 113 type sequence F description binding site for residue JE1 B 601 source : AC8 5) chain B residue 218 type sequence T description binding site for residue JE1 B 601 source : AC8 6) chain B residue 219 type sequence T description binding site for residue JE1 B 601 source : AC8 7) chain B residue 250 type sequence E description binding site for residue JE1 B 601 source : AC8 8) chain B residue 253 type sequence T description binding site for residue JE1 B 601 source : AC8 9) chain B residue 254 type sequence L description binding site for residue JE1 B 601 source : AC8 10) chain B residue 257 type sequence Q description binding site for residue JE1 B 601 source : AC8 11) chain B residue 489 type sequence D description binding site for residue JE1 B 601 source : AC8 12) chain B residue 491 type sequence P description binding site for residue JE1 B 601 source : AC8 13) chain B residue 492 type sequence K description binding site for residue JE1 B 601 source : AC8 14) chain B residue 495 type sequence Q description binding site for residue JE1 B 601 source : AC8 15) chain B residue 32 type sequence R description binding site for residue PO4 B 602 source : AC9 16) chain B residue 34 type sequence S description binding site for residue PO4 B 602 source : AC9 17) chain B residue 35 type sequence K description binding site for residue PO4 B 602 source : AC9 18) chain B residue 36 type sequence S description binding site for residue PO4 B 602 source : AC9 19) chain B residue 42 type sequence T description binding site for residue PO4 B 602 source : AC9 20) chain B residue 111 type sequence R description binding site for residue PO4 B 603 source : AD1 21) chain B residue 195 type sequence E description binding site for residue PO4 B 603 source : AD1 22) chain B residue 198 type sequence K description binding site for residue PO4 B 603 source : AD1 23) chain B residue 257 type sequence Q description binding site for residue PO4 B 603 source : AD1 24) chain B residue 260 type sequence K description binding site for residue PO4 B 603 source : AD1 25) chain B residue 131 type sequence K description binding site for residue PO4 B 604 source : AD2 26) chain B residue 217 type sequence N description binding site for residue PO4 B 604 source : AD2 27) chain B residue 220 type sequence R description binding site for residue PO4 B 604 source : AD2 28) chain B residue 346 type sequence F description binding site for residue PO4 B 605 source : AD3 29) chain B residue 347 type sequence Q description binding site for residue PO4 B 605 source : AD3 30) chain B residue 349 type sequence N description binding site for residue PO4 B 605 source : AD3 31) chain B residue 413 type sequence R description binding site for residue PO4 B 605 source : AD3 32) chain B residue 138 type sequence R description binding site for residue PO4 B 606 source : AD4 33) chain B residue 140 type sequence S description binding site for residue PO4 B 606 source : AD4 34) chain B residue 141 type sequence Q description binding site for residue PO4 B 606 source : AD4 35) chain B residue 142 type sequence S description binding site for residue PO4 B 606 source : AD4 36) chain B residue 425 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 459 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 506 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 459 type ACT_SITE sequence C description Phosphocysteine intermediate source Swiss-Prot : SWS_FT_FI1 40) chain B residue 62 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI4 41) chain B residue 66 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P35235 source Swiss-Prot : SWS_FT_FI5

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