eF-site ID 6md7-A PDB Code 6md7 Chain A click to enlarge Title Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Pyrimidinone 7 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Tyrosine-protein phosphatase non-receptor type 11 Source (PTN11_HUMAN) Sequence A:  SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFT LSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYM EHHGQLKENGDVIELKYPLNCADPTSERWFHGHLSGKEAE KLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDNDGKSKVT HVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGT VLQLKQPLNTTRINAAEIESRVRELSKLQGFWEEFETLQQ QECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGD PPVSDYINANIIMPEKSYIATQGCLQNTVNDFWRMVFQEN SRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVK ESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVP SDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTF IVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEA QYRFIYMAVQHYIETL Description Functional site 1) chain A residue 108 type sequence T description binding site for residue JE1 A 601 source : AC1 2) chain A residue 110 type sequence E description binding site for residue JE1 A 601 source : AC1 3) chain A residue 111 type sequence R description binding site for residue JE1 A 601 source : AC1 4) chain A residue 113 type sequence F description binding site for residue JE1 A 601 source : AC1 5) chain A residue 114 type sequence H description binding site for residue JE1 A 601 source : AC1 6) chain A residue 218 type sequence T description binding site for residue JE1 A 601 source : AC1 7) chain A residue 219 type sequence T description binding site for residue JE1 A 601 source : AC1 8) chain A residue 250 type sequence E description binding site for residue JE1 A 601 source : AC1 9) chain A residue 253 type sequence T description binding site for residue JE1 A 601 source : AC1 10) chain A residue 254 type sequence L description binding site for residue JE1 A 601 source : AC1 11) chain A residue 257 type sequence Q description binding site for residue JE1 A 601 source : AC1 12) chain A residue 489 type sequence D description binding site for residue JE1 A 601 source : AC1 13) chain A residue 492 type sequence K description binding site for residue JE1 A 601 source : AC1 14) chain A residue 495 type sequence Q description binding site for residue JE1 A 601 source : AC1 15) chain A residue 32 type sequence R description binding site for residue PO4 A 602 source : AC2 16) chain A residue 34 type sequence S description binding site for residue PO4 A 602 source : AC2 17) chain A residue 35 type sequence K description binding site for residue PO4 A 602 source : AC2 18) chain A residue 36 type sequence S description binding site for residue PO4 A 602 source : AC2 19) chain A residue 42 type sequence T description binding site for residue PO4 A 602 source : AC2 20) chain A residue 195 type sequence E description binding site for residue PO4 A 603 source : AC3 21) chain A residue 198 type sequence K description binding site for residue PO4 A 603 source : AC3 22) chain A residue 257 type sequence Q description binding site for residue PO4 A 603 source : AC3 23) chain A residue 260 type sequence K description binding site for residue PO4 A 603 source : AC3 24) chain A residue 131 type sequence K description binding site for residue PO4 A 604 source : AC4 25) chain A residue 217 type sequence N description binding site for residue PO4 A 604 source : AC4 26) chain A residue 220 type sequence R description binding site for residue PO4 A 604 source : AC4 27) chain A residue 492 type sequence K description binding site for residue PO4 A 604 source : AC4 28) chain A residue 346 type sequence F description binding site for residue PO4 A 605 source : AC5 29) chain A residue 347 type sequence Q description binding site for residue PO4 A 605 source : AC5 30) chain A residue 349 type sequence N description binding site for residue PO4 A 605 source : AC5 31) chain A residue 413 type sequence R description binding site for residue PO4 A 605 source : AC5 32) chain A residue 62 type sequence Y description binding site for residue PO4 A 606 source : AC6 33) chain A residue 70 type sequence K description binding site for residue PO4 A 606 source : AC6 34) chain A residue 279 type sequence Y description binding site for residue PO4 A 606 source : AC6 35) chain A residue 364 type sequence K description binding site for residue PO4 A 606 source : AC6 36) chain A residue 366 type sequence K description binding site for residue PO4 A 606 source : AC6 37) chain A residue 138 type sequence R description binding site for residue PO4 A 607 source : AC7 38) chain A residue 140 type sequence S description binding site for residue PO4 A 607 source : AC7 39) chain A residue 141 type sequence Q description binding site for residue PO4 A 607 source : AC7 40) chain A residue 142 type sequence S description binding site for residue PO4 A 607 source : AC7 41) chain A residue 425 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 459 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 506 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 459 type ACT_SITE sequence C description Phosphocysteine intermediate source Swiss-Prot : SWS_FT_FI1 45) chain A residue 62 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI4 46) chain A residue 66 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P35235 source Swiss-Prot : SWS_FT_FI5 47) chain A residue 457-467 type prosite sequence VHCSAGIGRTG description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG source prosite : PS00383

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