eF-site ID 6mam-ABCDEFGHIJKL PDB Code 6mam Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946 Classification Viral protein/immune system Compound ADI-15946 Fab Heavy Chain Source (VGP_EBOZM) Sequence A:  EVQLVESGGGLVKPGGSLRLSCAASGFTFSNAWMSWVRQA PGKGLEWVGRIKSKTDGGTIDYAAPVKGRFTISRDDSKNT VYLQMTSLKTEDTAVYYCTTYTEDMRYFDWLLRGGETFDY WGQGTLVTVSSASTKGPSVFPLAPSGGTAALGCLVKDYFP EPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSS SLGTQTYICNVNHKPSNTKVDKKVEP B:  DIRLTQSPSSLSASVGDRVTITCRASHYISTYLNWYQQKP GKAPKLLIYAASNLQSGVPSRFSGSGFGTDFSLTISSLQP EDFATYHCQQSYSTPGRYTFGQGTKVEIKRTVAAPSVFIF PPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLRSPVTKSFNRGE C:  EVQLVESGGGLVKPGGSLRLSCAASGFTFSNAWMSWVRQA PGKGLEWVGRIKSKTDGGTIDYAAPVKGRFTISRDDSKNT VYLQMTSLKTEDTAVYYCTTYTEDMRYFDWLLRGGETFDY WGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPE PVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSS LGTQTYICNVNHKPSNTKVDKKVEPKSCDLEVD D:  DIRLTQSPSSLSASVGDRVTITCRASHYISTYLNWYQQKP GKAPKLLIYAASNLQSGVPSRFSGSGFGTDFSLTISSLQP EDFATYHCQQSYSTPGRYTFGQGTKVEIKRTVAAPSVFIF PPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLRSPVTKSFNRGE E:  EVQLVESGGGLVKPGGSLRLSCAASGFTFSNAWMSWVRQA PGKGLEWVGRIKSKTDGGTIDYAAPVKGRFTISRDDSKNT VYLQMTSLKTEDTAVYYCTTYTEDMRYFDWLLRGGETFDY WGQGTLVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYF PEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPS SSLGTQTYICNVNHKPSNTKVDKKVEPCDLEVDDD F:  DIRLTQSPSSLSASVGDRVTITCRASHYISTYLNWYQQKP GKAPKLLIYAASNLQSGVPSRFSGSGFGTDFSLTISSLQP EDFATYHCQQSYSTPGRYTFGQGTKVEIKRTVAAPSVFIF PPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTH QGLRSPVTKSFNRGEC G:  SIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLE GNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNL EIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDF AFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILPQ H:  IVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIY IEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFS ILNRKAIDFLLQRWGGTCHILGPDCCIE I:  SIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLE GNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNL EIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDF AFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILP J:  EAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEG IYIEGLMHNQDGLICGLRQLANETTQALQLFLRATTELRT FSILNRKAIDFLLQRWGGTCHILGPDCCI K:  SIPLGVIHNSTLQVSDVDKLVCRDKLSSTNQLRSVGLNLE GNGVATDVPSATKRWGFRSGVPPKVVNYEAGEWAENCYNL EIKKPDGSECLPAAPDGIRGFPRCRYVHKVSGTGPCAGDF AFHKEGAFFLYDRLASTVIYRGTTFAEGVVAFLILP L:  IVNAQPKCNPNLHYWTTQDEAIGLAWIPYFGPAAEGIYIE GLMHNQDGLICGLRQLANETTQALQLFLRATTELRTFSIL NRKAIDFLLQRWGGTCHILGPDCCI Description Functional site 1) chain B residue 194-200 type prosite sequence YACEVTH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290 2) chain A residue 212-218 type prosite sequence YICNVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH source prosite : PS00290 3) chain G residue 57 type SITE sequence L description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain I residue 88 type SITE sequence F description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain I residue 95 type SITE sequence K description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 6) chain I residue 170 type SITE sequence I description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 7) chain K residue 57 type SITE sequence L description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 8) chain K residue 63 type SITE sequence L description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 9) chain K residue 64 type SITE sequence R description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 10) chain K residue 88 type SITE sequence F description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 11) chain K residue 95 type SITE sequence K description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain K residue 170 type SITE sequence I description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain G residue 63 type SITE sequence L description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain G residue 64 type SITE sequence R description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 15) chain G residue 88 type SITE sequence F description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 16) chain G residue 95 type SITE sequence K description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 17) chain G residue 170 type SITE sequence I description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 18) chain I residue 57 type SITE sequence L description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 19) chain I residue 63 type SITE sequence L description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 20) chain I residue 64 type SITE sequence R description Involved in receptor recognition and/or post-binding events => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 21) chain G residue 40 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 22) chain I residue 40 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 23) chain K residue 40 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine; by host => ECO:0000255 source Swiss-Prot : SWS_FT_FI3

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