eF-site ID 6ma7-A PDB Code 6ma7 Chain A click to enlarge Title Human CYP3A4 bound to an inhibitor fluconazole Classification OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR Compound Cytochrome P450 3A4 Source (CP3A4_HUMAN) Sequence A:  GTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECH KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR RPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEM VPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVIT STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITV FPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTD FLQLMIDSQNSSHKALSDLELVAQSIIFIFAGYETTSSVL SFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVV MIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTP FGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP LKLSLGGLLQPEKPVVLKVESRD Description Functional site 1) chain A residue 105 type sequence R description binding site for residue HEM A 601 source : AC1 2) chain A residue 118 type sequence I description binding site for residue HEM A 601 source : AC1 3) chain A residue 119 type sequence S description binding site for residue HEM A 601 source : AC1 4) chain A residue 126 type sequence W description binding site for residue HEM A 601 source : AC1 5) chain A residue 130 type sequence R description binding site for residue HEM A 601 source : AC1 6) chain A residue 137 type sequence F description binding site for residue HEM A 601 source : AC1 7) chain A residue 302 type sequence F description binding site for residue HEM A 601 source : AC1 8) chain A residue 305 type sequence A description binding site for residue HEM A 601 source : AC1 9) chain A residue 306 type sequence G description binding site for residue HEM A 601 source : AC1 10) chain A residue 370 type sequence A description binding site for residue HEM A 601 source : AC1 11) chain A residue 375 type sequence R description binding site for residue HEM A 601 source : AC1 12) chain A residue 434 type sequence P description binding site for residue HEM A 601 source : AC1 13) chain A residue 435 type sequence F description binding site for residue HEM A 601 source : AC1 14) chain A residue 436 type sequence G description binding site for residue HEM A 601 source : AC1 15) chain A residue 437 type sequence S description binding site for residue HEM A 601 source : AC1 16) chain A residue 440 type sequence R description binding site for residue HEM A 601 source : AC1 17) chain A residue 441 type sequence N description binding site for residue HEM A 601 source : AC1 18) chain A residue 442 type sequence C description binding site for residue HEM A 601 source : AC1 19) chain A residue 443 type sequence I description binding site for residue HEM A 601 source : AC1 20) chain A residue 444 type sequence G description binding site for residue HEM A 601 source : AC1 21) chain A residue 105 type sequence R description binding site for residue TPF A 602 source : AC2 22) chain A residue 212 type sequence R description binding site for residue TPF A 602 source : AC2 23) chain A residue 305 type sequence A description binding site for residue TPF A 602 source : AC2 24) chain A residue 369 type sequence I description binding site for residue TPF A 602 source : AC2 25) chain A residue 370 type sequence A description binding site for residue TPF A 602 source : AC2 26) chain A residue 119 type sequence S description binding site for residue DMS A 603 source : AC3 27) chain A residue 304 type sequence F description binding site for residue DMS A 603 source : AC3 28) chain A residue 177 type sequence G description binding site for residue EDO A 604 source : AC4 29) chain A residue 178 type sequence A description binding site for residue EDO A 604 source : AC4 30) chain A residue 181 type sequence M description binding site for residue EDO A 604 source : AC4 31) chain A residue 195 type sequence S description binding site for residue EDO A 604 source : AC4 32) chain A residue 204 type sequence V description binding site for residue EDO A 604 source : AC4 33) chain A residue 307 type sequence Y description binding site for residue EDO A 604 source : AC4 34) chain A residue 442 type BINDING sequence C description axial binding residue => ECO:0007744|PDB:1TQN, ECO:0007744|PDB:1W0G source Swiss-Prot : SWS_FT_FI1 35) chain A residue 435-444 type prosite sequence FGSGPRNCIG description CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGsGPRNCIG source prosite : PS00086

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