eF-site ID 6m7i-A PDB Code 6m7i Chain A click to enlarge Title Crystal structure of KPC-2 with compound 3 Classification HYDROLASE/INHIBITOR Compound Carbapenem-hydrolyzing beta-lactamase KPC Source (BLKPC_KLEPN) Sequence A:  MLTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYRAEE RFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVP WSPISEKYLTTGMTVAELSAAAVQYSDNAAANLLLKELGG PAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTSSPR AVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAA VPADWAVGDKTGTCGVYGTANDYAVVWPTGRAPIVLAVYT RAPNKDDKHSEAVIAAAARLALEGLGV Description Functional site 1) chain A residue 230 type sequence A description binding site for residue J84 A 301 source : AC1 2) chain A residue 251 type sequence W description binding site for residue J84 A 301 source : AC1 3) chain A residue 252 type sequence P description binding site for residue J84 A 301 source : AC1 4) chain A residue 255 type sequence G description binding site for residue J84 A 301 source : AC1 5) chain A residue 256 type sequence R description binding site for residue J84 A 301 source : AC1 6) chain A residue 257 type sequence A description binding site for residue J84 A 301 source : AC1 7) chain A residue 88 type sequence A description binding site for residue J84 A 302 source : AC2 8) chain A residue 167 type sequence L description binding site for residue J84 A 302 source : AC2 9) chain A residue 170 type sequence N description binding site for residue J84 A 302 source : AC2 10) chain A residue 171 type sequence S description binding site for residue J84 A 302 source : AC2 11) chain A residue 237 type sequence T description binding site for residue J84 A 302 source : AC2 12) chain A residue 238 type sequence C description binding site for residue J84 A 302 source : AC2 13) chain A residue 239 type sequence G description binding site for residue J84 A 302 source : AC2 14) chain A residue 240 type sequence V description binding site for residue J84 A 302 source : AC2 15) chain A residue 70 type sequence S description binding site for residue J84 A 303 source : AC3 16) chain A residue 85 type sequence Q description binding site for residue J84 A 303 source : AC3 17) chain A residue 88 type sequence A description binding site for residue J84 A 303 source : AC3 18) chain A residue 105 type sequence W description binding site for residue J84 A 303 source : AC3 19) chain A residue 130 type sequence S description binding site for residue J84 A 303 source : AC3 20) chain A residue 132 type sequence N description binding site for residue J84 A 303 source : AC3 21) chain A residue 167 type sequence L description binding site for residue J84 A 303 source : AC3 22) chain A residue 235 type sequence T description binding site for residue J84 A 303 source : AC3 23) chain A residue 236 type sequence G description binding site for residue J84 A 303 source : AC3 24) chain A residue 237 type sequence T description binding site for residue J84 A 303 source : AC3 25) chain A residue 105 type sequence W description binding site for residue J84 A 304 source : AC4 26) chain A residue 107 type sequence P description binding site for residue J84 A 304 source : AC4 27) chain A residue 129 type sequence Y description binding site for residue J84 A 304 source : AC4 28) chain A residue 146 type sequence A description binding site for residue J84 A 304 source : AC4 29) chain A residue 150 type sequence A description binding site for residue J84 A 304 source : AC4 30) chain A residue 151 type sequence F description binding site for residue J84 A 304 source : AC4 31) chain A residue 154 type sequence S description binding site for residue J84 A 304 source : AC4 32) chain A residue 205 type sequence Q description binding site for residue GOL A 305 source : AC5 33) chain A residue 212 type sequence K description binding site for residue GOL A 305 source : AC5 34) chain A residue 251 type sequence W description binding site for residue GOL A 305 source : AC5 35) chain A residue 70 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain A residue 168 type ACT_SITE sequence E description Proton acceptor => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 234 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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