eF-site ID 6ke0-B PDB Code 6ke0 Chain B click to enlarge Title Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor Classification HYDROLASE Compound cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Source (PDE10_HUMAN) Sequence B:  HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMW PGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHN WKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLD HRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLE EMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTK LTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQ LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVI RGEE Description Functional site 1) chain B residue 529 type sequence H description binding site for residue ZN B 801 source : AC4 2) chain B residue 563 type sequence H description binding site for residue ZN B 801 source : AC4 3) chain B residue 564 type sequence D description binding site for residue ZN B 801 source : AC4 4) chain B residue 674 type sequence D description binding site for residue ZN B 801 source : AC4 5) chain B residue 564 type sequence D description binding site for residue MG B 802 source : AC5 6) chain B residue 592 type sequence E description binding site for residue MG B 802 source : AC5 7) chain B residue 562 type BINDING sequence C description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF source Swiss-Prot : SWS_FT_FI1 8) chain B residue 606 type BINDING sequence E description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF source Swiss-Prot : SWS_FT_FI1 9) chain B residue 640 type BINDING sequence G description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF source Swiss-Prot : SWS_FT_FI1 10) chain B residue 659 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF source Swiss-Prot : SWS_FT_FI1

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