eF-site ID 6ke0-A
PDB Code 6ke0
Chain A

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Title Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor
Classification HYDROLASE
Compound cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
Source (PDE10_HUMAN)
Sequence A:  HMSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMW
PGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHN
WKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLD
HRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLE
GHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLE
EMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTK
LTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQ
LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVI
RGEE
Description


Functional site

1) chain A
residue 529
type
sequence H
description binding site for residue ZN A 801
source : AC1

2) chain A
residue 563
type
sequence H
description binding site for residue ZN A 801
source : AC1

3) chain A
residue 564
type
sequence D
description binding site for residue ZN A 801
source : AC1

4) chain A
residue 674
type
sequence D
description binding site for residue ZN A 801
source : AC1

5) chain A
residue 564
type
sequence D
description binding site for residue MG A 802
source : AC2

6) chain A
residue 592
type
sequence E
description binding site for residue MG A 802
source : AC2

7) chain A
residue 693
type
sequence Y
description binding site for residue D7C A 803
source : AC3

8) chain A
residue 712
type
sequence P
description binding site for residue D7C A 803
source : AC3

9) chain A
residue 713
type
sequence M
description binding site for residue D7C A 803
source : AC3

10) chain A
residue 725
type
sequence G
description binding site for residue D7C A 803
source : AC3

11) chain A
residue 726
type
sequence Q
description binding site for residue D7C A 803
source : AC3

12) chain A
residue 729
type
sequence F
description binding site for residue D7C A 803
source : AC3

13) chain A
residue 563-574
type prosite
sequence HDLDHRGFSNSY
description PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY
source prosite : PS00126

14) chain A
residue 562
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
source Swiss-Prot : SWS_FT_FI1

15) chain A
residue 606
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 640
type BINDING
sequence G
description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 659
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:18477562, ECO:0007744|PDB:2ZMF
source Swiss-Prot : SWS_FT_FI1


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