eF-site ID 6k72-ABCDEFGHIJKLMP PDB Code 6k72 Chain A, B, C, D, E, F, G, H, I, J, K, L, M, P Title eIF2(aP) - eIF2B complex Classification TRANSLATION Compound Translation initiation factor eIF-2B subunit alpha Source (IF2G_HUMAN) Sequence A:  KELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQ GLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEY SDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGA TILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKK MAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVEN GGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQ QDVPDKFKYHPWVDYTAPSLITLLFTDLGVLTPSAVSDEL IKLYL B:  ELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGETIQG LRANLTSAIETLCGVDSSVAVSSGGELFLRFISLASLEYS DYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIKDGAT ILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGKKM AKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENG GIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQ DVPDKFKYHPWVDYTAPSLITLLFTDLGVLTPSAVSDELI KLYL C:  GSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIIT DHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLK IIREEYGRLHGHYAQLQSNIIEAINELLVELEGTMENIAA QALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAE CAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVI IGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFK LSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVF DYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL D:  GSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIIT DHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLK IIREEYGRLHGHYAQLQSNIIEAINELLVELEGTMENIAA QALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAE CAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVI IGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFK LSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVF DYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL E:  MEFQAVVMAVGGPLLPVGNKPLIWYPLNLLERVGFEEVIV VTTKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKL KTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKRDF IGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHT GLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKSS QSLDIYSFITLNLAPYDACWNACRGDRWEDSSAQIVSKHL VGVDSLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCL LMNSVTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQR IEAKAKRVNEVIV F:  MEFQAVVMAVGGPLLPVGNKPLIWYPLNLLERVGFEEVIV VTTKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPKL KTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKRDF IGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFHT GLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKSS QSLDIYSFIAPYDACWNACRGDRWEDSSAQIVSKHLVGVD SLIGPETQIGEKSSIKRSVIGSSCLIKDRVTITNCLLMNS VTVEEGSNIQGSVICNNAVIEKGADIKDCLIGSGQRIEAK AKRVNEVIV G:  QVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHP AMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPN EELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEIT SVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQ KISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRP WLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGA HALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCE RVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLL NLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD H:  QVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHP AMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPN EELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEIT SVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQ KISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRP WLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGA HALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCE RVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLL NLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKSSD I:  PPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTL EFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVV RIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNIN ITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDN VVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEV RYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNN QIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYPLTPEA NFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSG TVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGVRVAAG AQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPE GSVISLHPPDAEEDEDDGEFS J:  PPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTL EFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVV RIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNIN ITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDN VVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEV RYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNN QIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYPLTPEA NFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENVLLGSG TVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGVRVAAG AQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPNITLPE GSVISLHPPDAEEDEDDGEFS K:  RFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMI RSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAI KCEDKFTKSKTVYSILRHVAEVDEQLESLFQRTAWVFDDK YKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLAVKIR ADIEVACYGYEGIDAVKEALRAGLNCSTENMPIKINLIAP PRYVMTTTTLERTEGLSVLSQAMAVIKEKIEEKRGVFNV L:  RFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMI LLIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKF TKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKY KRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINR RLTPQ M:  DYTYEELLNRVFNIMR P:  ATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITI KLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPG TKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLI AGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQ AKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYI VKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVA GGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIV SLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLG AVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLS KNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGE KIALSRRVEKHWRLIGWGQIR Description Functional site 1) chain P residue 51 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P32481 source Swiss-Prot : SWS_FT_FI1 2) chain P residue 190 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P32481 source Swiss-Prot : SWS_FT_FI1 3) chain P residue 225 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P32481 source Swiss-Prot : SWS_FT_FI1 4) chain L residue 141 type MOD_RES sequence K description Phosphoserine => ECO:0000250|UniProtKB:Q9Z0N1 source Swiss-Prot : SWS_FT_FI3 5) chain J residue 130 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q9Z0N1 source Swiss-Prot : SWS_FT_FI3 6) chain J residue 466 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI5 7) chain J residue 217 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI8 8) chain I residue 103 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI8 9) chain I residue 141 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI8 10) chain I residue 217 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI8 11) chain J residue 61 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI8 12) chain J residue 103 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI8 13) chain J residue 141 type MOD_RES sequence K description Phosphoserine => ECO:0007744|PubMed:20068231 source Swiss-Prot : SWS_FT_FI8

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