|
|
eF-site ID
|
6k3j_20-AB |
|
PDB Code
|
6k3j |
|
Model
|
20 |
|
Chain
|
A, B |
|
click to enlarge
|
|
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Title
|
Solution structure of APOBEC3G-CD2 with ssDNA, Product A |
|
Classification
|
HYDROLASE/DNA |
|
Compound
|
DNA dC->dU-editing enzyme APOBEC-3G |
|
Source
|
(6K3J) |
|
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Sequence
|
A: |
MDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLN
QRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQD
YRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYD
DQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGC
PFQPWDGLDEHSQDLSGRLRAILQNQEN
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| B: |
ATTCXXAATT
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
257 |
| type |
|
| sequence |
H
|
| description |
binding site for residue ZN A 401
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
288 |
| type |
|
| sequence |
C
|
| description |
binding site for residue ZN A 401
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
291 |
| type |
|
| sequence |
C
|
| description |
binding site for residue ZN A 401
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
257-295 |
| type |
prosite |
| sequence |
HAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEM
|
| description |
CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElcFLdvipfwkldldqdyrvtcftsws..........PCfs......CaqeM
|
| source |
prosite : PS00903
|
|
|
5)
|
chain |
A |
| residue |
259 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Proton donor => ECO:0000255|PROSITE-ProRule:PRU01083, ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:18849968, ECO:0000269|PubMed:19153609, ECO:0000269|PubMed:25542899, ECO:0000269|PubMed:36754086, ECO:0007744|PDB:4ROV, ECO:0007744|PDB:4ROW, ECO:0007744|PDB:8CX0, ECO:0007744|PDB:8CX1
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
A |
| residue |
257 |
| type |
BINDING |
| sequence |
H
|
| description |
BINDING => ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:18849968, ECO:0000269|PubMed:19153609, ECO:0000269|PubMed:25542899, ECO:0000269|PubMed:36754086, ECO:0000269|PubMed:37419875, ECO:0007744|PDB:4ROV, ECO:0007744|PDB:4ROW, ECO:0007744|PDB:8CX0, ECO:0007744|PDB:8CX1, ECO:0007744|PDB:8H0I, ECO:0007744|PDB:8J62
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
7)
|
chain |
A |
| residue |
288 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:18849968, ECO:0000269|PubMed:19153609, ECO:0000269|PubMed:25542899, ECO:0000269|PubMed:36754086, ECO:0000269|PubMed:37419875, ECO:0007744|PDB:4ROV, ECO:0007744|PDB:4ROW, ECO:0007744|PDB:8CX0, ECO:0007744|PDB:8CX1, ECO:0007744|PDB:8H0I, ECO:0007744|PDB:8J62
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
8)
|
chain |
A |
| residue |
291 |
| type |
BINDING |
| sequence |
C
|
| description |
BINDING => ECO:0000269|PubMed:18288108, ECO:0000269|PubMed:18849968, ECO:0000269|PubMed:19153609, ECO:0000269|PubMed:25542899, ECO:0000269|PubMed:36754086, ECO:0000269|PubMed:37419875, ECO:0007744|PDB:4ROV, ECO:0007744|PDB:4ROW, ECO:0007744|PDB:8CX0, ECO:0007744|PDB:8CX1, ECO:0007744|PDB:8H0I, ECO:0007744|PDB:8J62
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
A |
| residue |
244 |
| type |
SITE |
| sequence |
N
|
| description |
Interaction with DNA => ECO:0000305
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
10)
|
chain |
A |
| residue |
218 |
| type |
MOD_RES |
| sequence |
T
|
| description |
Phosphothreonine; by PKA and CAMK2 => ECO:0000269|PubMed:21659520
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
11)
|
chain |
A |
| residue |
249 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:23318957, ECO:0000305|PubMed:31253590
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
12)
|
chain |
A |
| residue |
297 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:19887642, ECO:0000305|PubMed:23318957, ECO:0000305|PubMed:31253590
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
13)
|
chain |
A |
| residue |
303 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:19887642, ECO:0000305|PubMed:23318957, ECO:0000305|PubMed:31253590
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
14)
|
chain |
A |
| residue |
334 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:19887642, ECO:0000305|PubMed:23318957, ECO:0000305|PubMed:31253590
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
15)
|
chain |
A |
| residue |
270 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:23318957
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
16)
|
chain |
A |
| residue |
301 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:19887642
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
|