eF-site ID 6jxj-A PDB Code 6jxj Chain A click to enlarge Title Rb+-bound E2-AlF state of the gastric proton pump (Tyr799Trp) Classification MEMBRANE PROTEIN Compound Potassium-transporting ATPase alpha chain 1 Source (ATP4B_PIG) Sequence A:  GMEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRDGP NALRPPRGTPEYVKFARQLAGGLQCLMWVAAAICLIAFAI QASEGDLTTDDNLYLALALIAVVVVTGCFGYYQEFKSTNI IASFKNLVPQQATVIRDGDKFQINADQLVVGDLVEMKGGD RVPADIRILQAQGCKVDNSSLTGESEPQTRSPECTHESPL ETRNIAFFSTMCLEGTAQGLVVNTGDRTIIGRIASLASGV ENEKTPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYTF LRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCV VKNLEAVETLGSTSVICSDKTGTLTQNRMTVSHLWFDNHI HSADTTEDQSGQTFDQSSETWRALCRVLTLCNRAAFKSGQ DAVPVPKRIVIGDASETALLKFSELTLGNAMGYRERFPKV CEIPFNSTNKFQLSIHTLEDPRDPRHVLVMKGAPERVLER CSSILIKGQELPLDEQWREAFQTAYLSLGGLGERVLGFCQ LYLSEKDYPPGYAFDVEAMNFPTSGLCFAGLVSMIDPPRA TVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGIISEG SETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMDPSE LVEALRTHPEMVFARTSPQQKLVIVESCQRLGAIVAVTGD GVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDDNFAS IVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPWLIYITVS VPLPLGCITILFIELCTDIFPSVSLAYEKAESDIMHLRPR NPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEG WFPLLCVGLRPQWENHHLQDLQDSYGQEWTFGQRLYQQYT CYTVFFISIEMCQIADVLIRKTRRLSAFQQGFFRNRILVI AIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPMPFSL LIFVYDEIRKLGVRCCPGSWWDQELYY Description Functional site 1) chain A residue 338 type BINDING sequence V description BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI5 2) chain A residue 339 type BINDING sequence A description BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI5 3) chain A residue 341 type BINDING sequence V description BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI5 4) chain A residue 343 type BINDING sequence E description BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI5 5) chain A residue 795 type BINDING sequence E description BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI5 6) chain A residue 820 type BINDING sequence E description BINDING => ECO:0000269|PubMed:31436534, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI5 7) chain A residue 996-1016 type TRANSMEM sequence QWWLVPMPFSLLIFVYDEIRK description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 141-161 type TRANSMEM sequence LALALIAVVVVTGCFGYYQEF description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 298-317 type TRANSMEM sequence EHFVDIIAGLAILFGATFFI description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 330-347 type TRANSMEM sequence MVFFMAIVVAYVPEGLLA description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 782-801 type TRANSMEM sequence KKSIAYTLTKNIPELTPWLI description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 812-832 type TRANSMEM sequence GCITILFIELCTDIFPSVSLA description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 853-875 type TRANSMEM sequence LVNEPLAAYSYFQIGAIQSFAGF description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 928-947 type TRANSMEM sequence YTVFFISIEMCQIADVLIRK description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 962-980 type TRANSMEM sequence RILVIAIVFQVCIGCFLCY description Helical; Signal-anchor for type II membrane protein => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 318-329 type TOPO_DOM sequence VAMCIGYTFLRA description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 802-811 type TOPO_DOM sequence YITVSVPLPL description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 876-927 type TOPO_DOM sequence TDYFTAMAQEGWFPLLCVGLRPQWENHHLQDLQDSYGQEW TFGQRLYQQYTC description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 981-995 type TOPO_DOM sequence CPGMPNIFNFMPIRF description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 385 type ACT_SITE sequence D description 4-aspartylphosphate intermediate => ECO:0000269|PubMed:1720615 source Swiss-Prot : SWS_FT_FI4 21) chain A residue 385 type BINDING sequence D description BINDING => ECO:0000269|PubMed:29618813, ECO:0000269|PubMed:31436534, ECO:0007744|PDB:5YLU, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI6 22) chain A residue 387 type BINDING sequence T description BINDING => ECO:0000269|PubMed:29618813, ECO:0000269|PubMed:31436534, ECO:0007744|PDB:5YLU, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI6 23) chain A residue 726 type BINDING sequence D description BINDING => ECO:0000269|PubMed:29618813, ECO:0000269|PubMed:31436534, ECO:0007744|PDB:5YLU, ECO:0007744|PDB:6JXH source Swiss-Prot : SWS_FT_FI6 24) chain A residue 730 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 25) chain A residue 461 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q6PIE5 source Swiss-Prot : SWS_FT_FI8 26) chain A residue 599 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P50993 source Swiss-Prot : SWS_FT_FI9 27) chain A residue 838 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P09626 source Swiss-Prot : SWS_FT_FI10 28) chain A residue 952 type MOD_RES sequence S description Phosphoserine; by PKA => ECO:0000250 source Swiss-Prot : SWS_FT_FI11 29) chain A residue 385-391 type prosite sequence DKTGTLT description ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT source prosite : PS00154

Display surface Download Links