eF-site ID 6jpb-ABCEF
PDB Code 6jpb
Chain A, B, C, E, F

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Title Rabbit Cav1.1-Diltiazem Complex
Classification MEMBRANE PROTEIN
Compound Voltage-dependent L-type calcium channel subunit alpha-1S
Source ORGANISM_COMMON: Rabbit; ORGANISM_SCIENTIFIC: Oryctolagus cuniculus;
Sequence A:  FCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVY
LPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFL
FHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVVKALRAF
RVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMV
IIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCAR
TGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQ
CITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILN
LVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYM
SWITQGEVMNRVFRWKCHDLVKSRVFYWLVILIVALNTLS
IASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGL
RQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLR
CIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFL
FIIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVF
QVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCG
NYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSV
RVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVR
NQILGYFDIAFTSVFTVEIVLKMTTYGYFNILDLLVVAVS
LISMVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT
IGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEE
CRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSL
FTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFII
YIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQ
CVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFAL
IMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMIL
KLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLS
AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVAL
LIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQA
VLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTC
GTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS
ILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPP
LGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVR
TALKIKTEGNFEQANEELRAIIKKIWKRTSMKLL
B:  QGPHMALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPS
PGDEVPVEGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGC
EVGFIPSPVKLDSLRLLQEQ
C:  VPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHL
FDGRISITRVTADISLARSSLAEVQSEIERIFELARTLQL
VALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKS
RGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDAC
EHLAEYLEAYWKATHPPS
E:  MSPTEAPKVRVTLFCILVGIVLAMTAVVSDHWAVLSPHCE
AAHFGLWRICTKRGEKNCSYFSISAAAISVFSLGFLIMGT
ICALMAFRKKRDYLLRPASMFYVFAGLCLFVSLEVMRQSV
KRMIEYYYSWSFACACAAFVLLFLGGISLLLFSLPRMPQN
PWESCMDAE
F:  FPSAVTIKSWVDKMQEDLVTLAKTASGVHQLVDIYEKYQD
LYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEK
VQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIK
PVFIDDANFRRQVSYQHAAVHIPTDIYEGSTIVLNELNWT
SALDDVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDN
SRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSG
LTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQH
LVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLN
YNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFT
FSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEY
LDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPV
FNITGQFENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTL
CPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTINLRKRRP
NVQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEK
TFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTY
SFYYIKAKIEETITQARYSETLKPDNFEESGYTFLAPRDY
CSDLKPSDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVL
LDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPK
EAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPG
AYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFT
KDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEI
DPSLMRHLVNISVYAFNKSYDYQSVCEPGAASKQSCITEQ
TQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMV
ESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDV
CFDNNVLEDYTDC
Description


Functional site
1) chain F
residue 261
type BINDING
sequence D
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
2) chain A
residue 1061-1118
type BINDING
sequence VGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRC
YIPKNPYQYQVWYVVTSS
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
3) chain A
residue 1171-1180
type BINDING
sequence AFKARGYFGD
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
4) chain A
residue 1251-1268
type BINDING
sequence EGVRTLLWTFIKSFQALP
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
5) chain F
residue 263
type BINDING
sequence S
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
6) chain F
residue 265
type BINDING
sequence S
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
7) chain A
residue 484-494
type BINDING
sequence YGLGLRQYFMS
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
8) chain A
residue 543-561
type BINDING
sequence TSLSNLVASLLNSIRSIAS
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
9) chain A
residue 654-799
type BINDING
sequence NVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSVRVLCH
RIVNAT
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
10) chain A
residue 912-930
type BINDING
sequence KGLKHVVQCVFVAIRTIGN
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI1
11) chain A
residue 433-451
type TRANSMEM
sequence VFYWLVILIVALNTLSIAS
description Helical; Name=S1 of repeat II => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI10
12) chain A
residue 463-483
type TRANSMEM
sequence LQDIANRVLLSLFTIEMLLKM
description Helical; Name=S2 of repeat II => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI11
13) chain A
residue 495-514
type TRANSMEM
sequence IFNRFDCFVVCSGILELLLV
description Helical; Name=S3 of repeat II => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI12
14) chain A
residue 524-542
type TRANSMEM
sequence ISVLRCIRLLRLFKITKYW
description Helical; Name=S4 of repeat II => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI13
15) chain A
residue 562-581
type TRANSMEM
sequence LLLLLFLFIIIFALLGMQLF
description Helical; Name=S5 of repeat II => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI14
16) chain A
residue 634-653
type TRANSMEM
sequence GVLVCIYFIILFVCGNYILL
description Helical; Name=S6 of repeat II => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI15
17) chain A
residue 800-818
type TRANSMEM
sequence WFTNFILLFILLSSAALAA
description Helical; Name=S1 of repeat III => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI16
18) chain A
residue 831-850
type TRANSMEM
sequence ILGYFDIAFTSVFTVEIVLK
description Helical; Name=S2 of repeat III => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI17
19) chain A
residue 893-911
type TRANSMEM
sequence VKILRVLRVLRPLRAINRA
description Helical; Name=S4 of repeat III => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI19
20) chain F
residue 119
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P54290
source Swiss-Prot : SWS_FT_FI2
21) chain E
residue 109-129
type MOD_RES
sequence AISVFSLGFLIMGTICALMAF
description Phosphoserine => ECO:0000250|UniProtKB:P54290
source Swiss-Prot : SWS_FT_FI2
22) chain E
residue 135-155
type MOD_RES
sequence YLLRPASMFYVFAGLCLFVSL
description Phosphoserine => ECO:0000250|UniProtKB:P54290
source Swiss-Prot : SWS_FT_FI2
23) chain E
residue 180-204
type MOD_RES
sequence WSFACACAAFVLLFLGGISLLLFSL
description Phosphoserine => ECO:0000250|UniProtKB:P54290
source Swiss-Prot : SWS_FT_FI2
24) chain A
residue 931-950
type TRANSMEM
sequence IVLVTTLLQFMFACIGVQLF
description Helical; Name=S5 of repeat III => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI20
25) chain A
residue 1039-1060
type TRANSMEM
sequence VEMAIFFIIYIILIAFFMMNIF
description Helical; Name=S6 of repeat III => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI21
26) chain A
residue 1119-1140
type TRANSMEM
sequence YFEYLMFALIMLNTICLGMQHY
description Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI22
27) chain A
residue 1149-1170
type TRANSMEM
sequence ISDILNVAFTIIFTLEMILKLL
description Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI23
28) chain A
residue 1181-1200
type TRANSMEM
sequence PWNVFDFLIVIGSIIDVILS
description Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI24
29) chain A
residue 1232-1250
type TRANSMEM
sequence SAFFRLFRVMRLIKLLSRA
description Helical; Name=S4 of repeat IV => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI25
30) chain A
residue 1269-1289
type TRANSMEM
sequence YVALLIVMLFFIYAVIGMQMF
description Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI26
31) chain A
residue 1357-1381
type TRANSMEM
sequence AYYYFISFYMLCAFLIINLFVAVIM
description Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI27
32) chain A
residue 292
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:27580036, ECO:0007744|PDB:5GJV
source Swiss-Prot : SWS_FT_FI28
33) chain A
residue 614
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:27580036, ECO:0007744|PDB:5GJV
source Swiss-Prot : SWS_FT_FI28
34) chain A
residue 1014
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:27580036, ECO:0007744|PDB:5GJV
source Swiss-Prot : SWS_FT_FI28
35) chain F
residue 92
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
36) chain A
residue 951-1000
type CARBOHYD
sequence KGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQW
IHNDFHFDNV
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
37) chain A
residue 1022-1038
type CARBOHYD
sequence RAIDSNEEDMGPVYNNR
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
38) chain A
residue 1141-1148
type CARBOHYD
sequence HQSEEMNH
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
39) chain A
residue 1290-1311
type CARBOHYD
sequence GKIALVDGTQINRNNNFQTFPQ
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
40) chain A
residue 1331-1356
type CARBOHYD
sequence ACSYGKLCDPESDYAPGEEYTCGTNF
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
41) chain F
residue 138
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
42) chain F
residue 186
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
43) chain F
residue 326
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
44) chain F
residue 350
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
45) chain F
residue 615
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
46) chain F
residue 785
type CARBOHYD
sequence K
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
47) chain F
residue 892
type CARBOHYD
sequence I
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
48) chain A
residue 819-830
type CARBOHYD
sequence EDPIRAESVRNQ
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI3
49) chain A
residue 687
type MOD_RES
sequence S
description Phosphoserine; by PKA => ECO:0000305|PubMed:2844809
source Swiss-Prot : SWS_FT_FI31
50) chain A
residue 79
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI34
51) chain A
residue 257
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0007744|PDB:5GJV
source Swiss-Prot : SWS_FT_FI35
52) chain E
residue 79
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI4
53) chain A
residue 116-136
type TRANSMEM
sequence AYLRSGWNVLDFIIVFLGVFT
description Helical; Name=S3 of repeat I => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI5
54) chain A
residue 161-179
type TRANSMEM
sequence VKALRAFRVLRPLRLVSGV
description Helical; Name=S4 of repeat I => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI6
55) chain A
residue 197-218
type TRANSMEM
sequence FHIALLVLFMVIIYAIIGLELF
description Helical; Name=S5 of repeat I => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI7
56) chain A
residue 280-301
type INTRAMEM
sequence FSMLTVYQCITMEGWTDVLYWV
description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI8
57) chain A
residue 602-623
type INTRAMEM
sequence QALISVFQVLTGEDWNSVMYNG
description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI8
58) chain A
residue 1001-1021
type INTRAMEM
sequence LSAMMSLFTVSTFEGWPQLLY
description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI8
59) chain A
residue 1312-1330
type INTRAMEM
sequence AVLLLFRCATGEAWQEILL
description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI8
60) chain A
residue 310-330
type TRANSMEM
sequence PWIYFVTLILLGSFFILNLVL
description Helical; Name=S6 of repeat I => ECO:0000269|PubMed:27580036
source Swiss-Prot : SWS_FT_FI9

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