eF-site ID 6jpb-A PDB Code 6jpb Chain A click to enlarge Title Rabbit Cav1.1-Diltiazem Complex Classification MEMBRANE PROTEIN Compound Voltage-dependent L-type calcium channel subunit alpha-1S Source ORGANISM_COMMON: Rabbit; ORGANISM_SCIENTIFIC: Oryctolagus cuniculus; Sequence A:  FCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVY LPMPEDDNNSLNLGLEKLEYFFLTVFSIEAAMKIIAYGFL FHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNVVKALRAF RVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMV IIYAIIGLELFKGKMHKTCYYIGTDIVATVENEKPSPCAR TGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQ CITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILN LVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYM SWITQGEVMNRVFRWKCHDLVKSRVFYWLVILIVALNTLS IASEHHNQPLWLTHLQDIANRVLLSLFTIEMLLKMYGLGL RQYFMSIFNRFDCFVVCSGILELLLVESGAMTPLGISVLR CIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFL FIIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVF QVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCG NYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSV RVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRAESVR NQILGYFDIAFTSVFTVEIVLKMTTYGYFNILDLLVVAVS LISMVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRT IGNIVLVTTLLQFMFACIGVQLFKGKFFSCNDLSKMTEEE CRGYYYVYKDGDPTQMELRPRQWIHNDFHFDNVLSAMMSL FTVSTFEGWPQLLYRAIDSNEEDMGPVYNNRVEMAIFFII YIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQ CVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFAL IMLNTICLGMQHYHQSEEMNHISDILNVAFTIIFTLEMIL KLLAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLS AFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVAL LIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQA VLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYTC GTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS ILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPP LGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVR TALKIKTEGNFEQANEELRAIIKKIWKRTSMKLL Description Functional site 1) chain A residue 1061-1118 type BINDING sequence VGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRC YIPKNPYQYQVWYVVTSS description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 2) chain A residue 1171-1180 type BINDING sequence AFKARGYFGD description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 1251-1268 type BINDING sequence EGVRTLLWTFIKSFQALP description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 484-494 type BINDING sequence YGLGLRQYFMS description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 543-561 type BINDING sequence TSLSNLVASLLNSIRSIAS description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 654-799 type BINDING sequence NVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSVRVLCH RIVNAT description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 912-930 type BINDING sequence KGLKHVVQCVFVAIRTIGN description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 433-451 type TRANSMEM sequence VFYWLVILIVALNTLSIAS description Helical; Name=S1 of repeat II => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI10 9) chain A residue 831-850 type TRANSMEM sequence ILGYFDIAFTSVFTVEIVLK description Helical; Name=S2 of repeat III => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI17 10) chain A residue 893-911 type TRANSMEM sequence VKILRVLRVLRPLRAINRA description Helical; Name=S4 of repeat III => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI19 11) chain A residue 292 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27580036, ECO:0007744|PDB:5GJV source Swiss-Prot : SWS_FT_FI28 12) chain A residue 614 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27580036, ECO:0007744|PDB:5GJV source Swiss-Prot : SWS_FT_FI28 13) chain A residue 1014 type BINDING sequence E description BINDING => ECO:0000269|PubMed:27580036, ECO:0007744|PDB:5GJV source Swiss-Prot : SWS_FT_FI28 14) chain A residue 463-483 type TRANSMEM sequence LQDIANRVLLSLFTIEMLLKM description Helical; Name=S2 of repeat II => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI11 15) chain A residue 495-514 type TRANSMEM sequence IFNRFDCFVVCSGILELLLV description Helical; Name=S3 of repeat II => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI12 16) chain A residue 524-542 type TRANSMEM sequence ISVLRCIRLLRLFKITKYW description Helical; Name=S4 of repeat II => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI13 17) chain A residue 562-581 type TRANSMEM sequence LLLLLFLFIIIFALLGMQLF description Helical; Name=S5 of repeat II => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI14 18) chain A residue 634-653 type TRANSMEM sequence GVLVCIYFIILFVCGNYILL description Helical; Name=S6 of repeat II => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI15 19) chain A residue 800-818 type TRANSMEM sequence WFTNFILLFILLSSAALAA description Helical; Name=S1 of repeat III => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI16 20) chain A residue 931-950 type TRANSMEM sequence IVLVTTLLQFMFACIGVQLF description Helical; Name=S5 of repeat III => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI20 21) chain A residue 1039-1060 type TRANSMEM sequence VEMAIFFIIYIILIAFFMMNIF description Helical; Name=S6 of repeat III => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI21 22) chain A residue 1119-1140 type TRANSMEM sequence YFEYLMFALIMLNTICLGMQHY description Helical; Name=S1 of repeat IV => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI22 23) chain A residue 1149-1170 type TRANSMEM sequence ISDILNVAFTIIFTLEMILKLL description Helical; Name=S2 of repeat IV => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI23 24) chain A residue 1181-1200 type TRANSMEM sequence PWNVFDFLIVIGSIIDVILS description Helical; Name=S3 of repeat IV => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI24 25) chain A residue 1232-1250 type TRANSMEM sequence SAFFRLFRVMRLIKLLSRA description Helical; Name=S4 of repeat IV => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI25 26) chain A residue 1269-1289 type TRANSMEM sequence YVALLIVMLFFIYAVIGMQMF description Helical; Name=S5 of repeat IV => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI26 27) chain A residue 1357-1381 type TRANSMEM sequence AYYYFISFYMLCAFLIINLFVAVIM description Helical; Name=S6 of repeat IV => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI27 28) chain A residue 951-1000 type CARBOHYD sequence KGKFFSCNDLSKMTEEECRGYYYVYKDGDPTQMELRPRQW IHNDFHFDNV description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 1022-1038 type CARBOHYD sequence RAIDSNEEDMGPVYNNR description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 1141-1148 type CARBOHYD sequence HQSEEMNH description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 31) chain A residue 1290-1311 type CARBOHYD sequence GKIALVDGTQINRNNNFQTFPQ description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 32) chain A residue 1331-1356 type CARBOHYD sequence ACSYGKLCDPESDYAPGEEYTCGTNF description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 33) chain A residue 819-830 type CARBOHYD sequence EDPIRAESVRNQ description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 34) chain A residue 116-136 type TRANSMEM sequence AYLRSGWNVLDFIIVFLGVFT description Helical; Name=S3 of repeat I => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI5 35) chain A residue 161-179 type TRANSMEM sequence VKALRAFRVLRPLRLVSGV description Helical; Name=S4 of repeat I => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI6 36) chain A residue 197-218 type TRANSMEM sequence FHIALLVLFMVIIYAIIGLELF description Helical; Name=S5 of repeat I => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI7 37) chain A residue 280-301 type INTRAMEM sequence FSMLTVYQCITMEGWTDVLYWV description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI8 38) chain A residue 602-623 type INTRAMEM sequence QALISVFQVLTGEDWNSVMYNG description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI8 39) chain A residue 1001-1021 type INTRAMEM sequence LSAMMSLFTVSTFEGWPQLLY description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI8 40) chain A residue 1312-1330 type INTRAMEM sequence AVLLLFRCATGEAWQEILL description Pore-forming => ECO:0000269|PubMed:26680202, ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI8 41) chain A residue 310-330 type TRANSMEM sequence PWIYFVTLILLGSFFILNLVL description Helical; Name=S6 of repeat I => ECO:0000269|PubMed:27580036 source Swiss-Prot : SWS_FT_FI9 42) chain A residue 687 type MOD_RES sequence S description Phosphoserine; by PKA => ECO:0000305|PubMed:2844809 source Swiss-Prot : SWS_FT_FI31 43) chain A residue 79 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI34 44) chain A residue 257 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0007744|PDB:5GJV source Swiss-Prot : SWS_FT_FI35

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