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eF-site ID
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6jmr-BCDEF |
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PDB Code
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6jmr |
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Chain
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B, C, D, E, F |
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click to enlarge
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Title
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CD98hc extracellular domain bound to HBJ127 Fab and MEM-108 Fab |
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Classification
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MEMBRANE PROTEIN/IMMUNE SYSTEM |
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Compound
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Antibody |
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Source
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(6JMR) |
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Sequence
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B: |
CRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLKGRLD
YLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFGSKED
FDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDTVATK
VKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQNITKG
FSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYLSDSG
STGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFLPAQL
LRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPMEAPVM
LWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRRLSDQ
RSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLVVLNF
GDVGLSAGLQASDLPASASLPAKADLLLSTQPGREEGSPL
ELERLKLEPHEGLLLRFPYAA
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| C: |
QVQLKESGPGLVAPSQSLSITCTVSGFPLTXXXXXWVRQP
PGKGLEWLGXXXXXXXXXXXXXXXXRLSISKDNSKSQVFL
KMNSLQTDDTARYYCARXXXXXXXXXXWGQGTSVTVSSAK
TTPPSVYPLAPGSSMVTLGCLVKGYFPEPVTVTWNSGSLS
SGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHP
ASSTKVDKKIVPRD
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| D: |
DIVMSQSPSSLVVSVGEKVTMSCXXXXXXXXXXXXXXXXX
WYQQKPGQSPKLLIYXXXXXXXGVPDRFTGSGSGTDFTLT
ISSVKAEDLAVYYCXXXXXXXXXFGGGTKLEIKRADAAPT
VSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSE
RQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTC
EATHKTSTSPIVKSFNRNE
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| E: |
QVKLLESGPGLVQPSQSLSITCTVSGFSLTTYGIHWVRQP
PGKGLEWLGVIWSNGRIDYNAAFISRLSITKDNSKSQVFF
KMNSLQDDDTAIYYCARNVYDSLTWFTYWGQGTLVTVSAA
KTTPPSVYPLAPGSSMVTLGCLVKGYFPEPVTVTWNSGSL
SSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAH
PASSTKVDKKIVPRD
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| F: |
DIQMTQSPSSLAVSVGEKVTMTCKSSQSLLYSSNQKNYLA
WYQQKPGQSPKLLIFWASTRESGVPDRFTGSGSGTDFPLT
ISSVKAEDLAVYFCQQYTSYPTFGGGTKLEIKRADAAPTV
SIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSER
QNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCE
ATHKTSTSPIVKSFNRNE
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Description
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(1) |
Antibody, 4F2 cell-surface antigen heavy chain
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Functional site
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1)
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chain |
D |
| residue |
198-204 |
| type |
prosite |
| sequence |
YTCEATH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
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| source |
prosite : PS00290
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2)
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chain |
F |
| residue |
197-203 |
| type |
prosite |
| sequence |
YTCEATH
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| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
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| source |
prosite : PS00290
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3)
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chain |
B |
| residue |
424 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
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| source |
Swiss-Prot : SWS_FT_FI10
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4)
|
chain |
B |
| residue |
506 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMH, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
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| source |
Swiss-Prot : SWS_FT_FI11
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5)
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chain |
B |
| residue |
406 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000305|PubMed:19065266
|
| source |
Swiss-Prot : SWS_FT_FI7
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6)
|
chain |
B |
| residue |
408 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000305|PubMed:19065266
|
| source |
Swiss-Prot : SWS_FT_FI7
|
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7)
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chain |
B |
| residue |
410 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000305|PubMed:19065266
|
| source |
Swiss-Prot : SWS_FT_FI7
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|
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8)
|
chain |
B |
| residue |
527 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000305|PubMed:19065266
|
| source |
Swiss-Prot : SWS_FT_FI7
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|
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9)
|
chain |
B |
| residue |
531 |
| type |
MOD_RES |
| sequence |
S
|
| description |
Phosphoserine => ECO:0000305|PubMed:19065266
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
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10)
|
chain |
B |
| residue |
365 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
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| source |
Swiss-Prot : SWS_FT_FI8
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|
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11)
|
chain |
B |
| residue |
381 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:30867591, ECO:0000269|PubMed:33298890, ECO:0000269|PubMed:33758168, ECO:0000269|PubMed:34880232, ECO:0000269|PubMed:35352032, ECO:0007744|PDB:6IRS, ECO:0007744|PDB:7CMI, ECO:0007744|PDB:7DSK, ECO:0007744|PDB:7EPZ, ECO:0007744|PDB:7P9V
|
| source |
Swiss-Prot : SWS_FT_FI9
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