eF-site/Summary 6jmq-B

eF-site ID	6jmq-B
PDB Code	6jmq
Chain	B

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Title	LAT1-CD98hc complex bound to MEM-108 Fab
Classification	MEMBRANE PROTEIN/IMMUNE SYSTEM
Compound	Large neutral amino acids transporter small subunit 1
Source	(6JMQ)

Sequence	B:	RTRWALLLLFWLGWLGMLAGAVVIIVRAPRCRELPAQKWW HTGALYRIGDLQAFQGHGAGNLAGLKGRLDYLSSLKVKGL VLGPIHKNQKDDVAQTDLLQIDPNFGSKEDFDSLLQSAKK KSIRVILDLTPNYRGENSWFSTQVDTVATKVKDALEFWLQ AGVDGFQVRDIENLKDASSFLAEWQNITKGFSEDRLLIAG TNSSDLQQILSLLESNKDLLLTSSYLSDSGSTGEHTKSLV TQYLNATGNRWCSWSLSQARLLTSFLPAQLLRLYQLMLFT LPGTPVFSYGDEIGLDAAALPGQPMEAPVMLWDESSFPDI PGAVSANMTVKGQSEDPGSLLSLFRRLSDQRSKERSLLHG DFHAFSAGPGLFSYIRHWDQNERFLVVLNFGDVGLSAGLQ ASDLPASASLPAKADLLLSTQPGREEGSPLELERLKLEPH EGLLLRFPYAA

Description	(1)	Large neutral amino acids transporter small subunit 1, 4F2 cell-surface antigen heavy chain, Antibody

Functional site


1)	chain	B
	residue	185-205
	type	TRANSMEM
	sequence	LLLLFWLGWLGMLAGAVVIIV
	description	Helical; Signal-anchor for type II membrane protein => ECO:0000269\|PubMed:30867591
	source	Swiss-Prot : SWS_FT_FI2

2)	chain	B
	residue	206-630
	type	TOPO_DOM
	sequence	RAPRCRELPAQKWWHTGALYRIGDLQAFQGHGAGNLAGLK GRLDYLSSLKVKGLVLGPIHKNQKDDVAQTDLLQIDPNFG SKEDFDSLLQSAKKKSIRVILDLTPNYRGENSWFSTQVDT VATKVKDALEFWLQAGVDGFQVRDIENLKDASSFLAEWQN ITKGFSEDRLLIAGTNSSDLQQILSLLESNKDLLLTSSYL SDSGSTGEHTKSLVTQYLNATGNRWCSWSLSQARLLTSFL PAQLLRLYQLMLFTLPGTPVFSYGDEIGLDAAALPGQPME APVMLWDESSFPDIPGAVSANMTVKGQSEDPGSLLSLFRR LSDQRSKERSLLHGDFHAFSAGPGLFSYIRHWDQNERFLV VLNFGDVGLSAGLQASDLPASASLPAKADLLLSTQPGREE GSPLELERLKLEPHEGLLLRFPYAA
	description	Extracellular => ECO:0000269\|PubMed:11121428, ECO:0000269\|PubMed:30867591
	source	Swiss-Prot : SWS_FT_FI3

3)	chain	B
	residue	406
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000305\|PubMed:19065266
	source	Swiss-Prot : SWS_FT_FI7

4)	chain	B
	residue	408
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000305\|PubMed:19065266
	source	Swiss-Prot : SWS_FT_FI7

5)	chain	B
	residue	410
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000305\|PubMed:19065266
	source	Swiss-Prot : SWS_FT_FI7

6)	chain	B
	residue	527
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000305\|PubMed:19065266
	source	Swiss-Prot : SWS_FT_FI7

7)	chain	B
	residue	531
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0000305\|PubMed:19065266
	source	Swiss-Prot : SWS_FT_FI7

8)	chain	B
	residue	424
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) (complex) asparagine => ECO:0000269\|PubMed:12754519, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19139490, ECO:0000269\|PubMed:19349973, ECO:0000269\|PubMed:30867591, ECO:0000269\|PubMed:33298890, ECO:0000269\|PubMed:33758168, ECO:0000269\|PubMed:34880232, ECO:0000269\|PubMed:35352032, ECO:0007744\|PDB:6IRS, ECO:0007744\|PDB:7CMI, ECO:0007744\|PDB:7DSK, ECO:0007744\|PDB:7EPZ, ECO:0007744\|PDB:7P9V
	source	Swiss-Prot : SWS_FT_FI10

9)	chain	B
	residue	506
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19349973, ECO:0000269\|PubMed:30867591, ECO:0000269\|PubMed:33298890, ECO:0000269\|PubMed:33758168, ECO:0000269\|PubMed:34880232, ECO:0000269\|PubMed:35352032, ECO:0007744\|PDB:6IRS, ECO:0007744\|PDB:7CMH, ECO:0007744\|PDB:7DSK, ECO:0007744\|PDB:7EPZ, ECO:0007744\|PDB:7P9V
	source	Swiss-Prot : SWS_FT_FI11

10)	chain	B
	residue	365
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12754519, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19349973, ECO:0000269\|PubMed:30867591, ECO:0000269\|PubMed:33298890, ECO:0000269\|PubMed:33758168, ECO:0000269\|PubMed:34880232, ECO:0000269\|PubMed:35352032, ECO:0007744\|PDB:6IRS, ECO:0007744\|PDB:7CMI, ECO:0007744\|PDB:7DSK, ECO:0007744\|PDB:7EPZ, ECO:0007744\|PDB:7P9V
	source	Swiss-Prot : SWS_FT_FI8

11)	chain	B
	residue	381
	type	CARBOHYD
	sequence	N
	description	N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:12754519, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19349973, ECO:0000269\|PubMed:30867591, ECO:0000269\|PubMed:33298890, ECO:0000269\|PubMed:33758168, ECO:0000269\|PubMed:34880232, ECO:0000269\|PubMed:35352032, ECO:0007744\|PDB:6IRS, ECO:0007744\|PDB:7CMI, ECO:0007744\|PDB:7DSK, ECO:0007744\|PDB:7EPZ, ECO:0007744\|PDB:7P9V
	source	Swiss-Prot : SWS_FT_FI9