eF-site ID 6jm9-X
PDB Code 6jm9
Chain X

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Title cryo-EM structure of DOT1L bound to unmodified nucleosome
Classification GENE REGULATION
Compound DNA strand I
Source (DOT1L_HUMAN)
Sequence X:  LELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWV
CEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDS
IHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEK
LNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGS
GVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRK
WMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFA
FGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNL
SDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILEN
YFSSLKNP
Description


Functional site

1) chain X
residue 133
type
sequence P
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

2) chain X
residue 135
type
sequence V
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

3) chain X
residue 136
type
sequence Y
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

4) chain X
residue 138
type
sequence E
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

5) chain X
residue 139
type
sequence T
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

6) chain X
residue 161
type
sequence D
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

7) chain X
residue 163
type
sequence G
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

8) chain X
residue 164
type
sequence S
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

9) chain X
residue 186
type
sequence E
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

10) chain X
residue 187
type
sequence K
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

11) chain X
residue 188
type
sequence A
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

12) chain X
residue 222
type
sequence D
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

13) chain X
residue 223
type
sequence F
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

14) chain X
residue 224
type
sequence L
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

15) chain X
residue 225
type
sequence S
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

16) chain X
residue 239
type
sequence F
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

17) chain X
residue 241
type
sequence N
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

18) chain X
residue 245
type
sequence F
description binding site for Di-peptide SAM X 500 and GLY X 137
source : AC1

19) chain X
residue 133
type
sequence P
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

20) chain X
residue 135
type
sequence V
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

21) chain X
residue 136
type
sequence Y
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

22) chain X
residue 137
type
sequence G
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

23) chain X
residue 138
type
sequence E
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

24) chain X
residue 139
type
sequence T
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

25) chain X
residue 161
type
sequence D
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

26) chain X
residue 163
type
sequence G
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

27) chain X
residue 164
type
sequence S
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

28) chain X
residue 185
type
sequence V
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

29) chain X
residue 186
type
sequence E
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

30) chain X
residue 187
type
sequence K
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

31) chain X
residue 188
type
sequence A
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

32) chain X
residue 222
type
sequence D
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

33) chain X
residue 224
type
sequence L
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

34) chain X
residue 225
type
sequence S
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

35) chain X
residue 239
type
sequence F
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

36) chain X
residue 241
type
sequence N
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

37) chain X
residue 245
type
sequence F
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC2

38) chain X
residue 133
type
sequence P
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

39) chain X
residue 135
type
sequence V
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

40) chain X
residue 136
type
sequence Y
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

41) chain X
residue 137
type
sequence G
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

42) chain X
residue 138
type
sequence E
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

43) chain X
residue 139
type
sequence T
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

44) chain X
residue 161
type
sequence D
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

45) chain X
residue 163
type
sequence G
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

46) chain X
residue 164
type
sequence S
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

47) chain X
residue 185
type
sequence V
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

48) chain X
residue 186
type
sequence E
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

49) chain X
residue 187
type
sequence K
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

50) chain X
residue 188
type
sequence A
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

51) chain X
residue 222
type
sequence D
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

52) chain X
residue 224
type
sequence L
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

53) chain X
residue 225
type
sequence S
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

54) chain X
residue 239
type
sequence F
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

55) chain X
residue 241
type
sequence N
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

56) chain X
residue 245
type
sequence F
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC3

57) chain X
residue 133
type
sequence P
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

58) chain X
residue 135
type
sequence V
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

59) chain X
residue 136
type
sequence Y
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

60) chain X
residue 137
type
sequence G
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

61) chain X
residue 138
type
sequence E
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

62) chain X
residue 139
type
sequence T
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

63) chain X
residue 161
type
sequence D
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

64) chain X
residue 163
type
sequence G
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

65) chain X
residue 164
type
sequence S
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

66) chain X
residue 185
type
sequence V
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

67) chain X
residue 186
type
sequence E
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

68) chain X
residue 187
type
sequence K
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

69) chain X
residue 188
type
sequence A
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

70) chain X
residue 222
type
sequence D
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

71) chain X
residue 224
type
sequence L
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

72) chain X
residue 225
type
sequence S
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

73) chain X
residue 239
type
sequence F
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

74) chain X
residue 241
type
sequence N
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

75) chain X
residue 245
type
sequence F
description binding site for Di-peptide SAM X 500 and PHE X 223
source : AC4

76) chain X
residue 133
type
sequence P
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

77) chain X
residue 135
type
sequence V
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

78) chain X
residue 136
type
sequence Y
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

79) chain X
residue 137
type
sequence G
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

80) chain X
residue 138
type
sequence E
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

81) chain X
residue 139
type
sequence T
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

82) chain X
residue 161
type
sequence D
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

83) chain X
residue 163
type
sequence G
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

84) chain X
residue 164
type
sequence S
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

85) chain X
residue 186
type
sequence E
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

86) chain X
residue 187
type
sequence K
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

87) chain X
residue 188
type
sequence A
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

88) chain X
residue 222
type
sequence D
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

89) chain X
residue 223
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

90) chain X
residue 225
type
sequence S
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

91) chain X
residue 239
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

92) chain X
residue 241
type
sequence N
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

93) chain X
residue 245
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

94) chain X
residue 253
type
sequence L
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

95) chain X
residue 256
type
sequence R
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC5

96) chain X
residue 133
type
sequence P
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

97) chain X
residue 135
type
sequence V
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

98) chain X
residue 136
type
sequence Y
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

99) chain X
residue 137
type
sequence G
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

100) chain X
residue 138
type
sequence E
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

101) chain X
residue 139
type
sequence T
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

102) chain X
residue 161
type
sequence D
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

103) chain X
residue 163
type
sequence G
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

104) chain X
residue 164
type
sequence S
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

105) chain X
residue 186
type
sequence E
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

106) chain X
residue 187
type
sequence K
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

107) chain X
residue 188
type
sequence A
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

108) chain X
residue 222
type
sequence D
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

109) chain X
residue 223
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

110) chain X
residue 225
type
sequence S
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

111) chain X
residue 239
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

112) chain X
residue 241
type
sequence N
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

113) chain X
residue 245
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

114) chain X
residue 253
type
sequence L
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

115) chain X
residue 256
type
sequence R
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC6

116) chain X
residue 133
type
sequence P
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

117) chain X
residue 135
type
sequence V
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

118) chain X
residue 136
type
sequence Y
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

119) chain X
residue 137
type
sequence G
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

120) chain X
residue 138
type
sequence E
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

121) chain X
residue 139
type
sequence T
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

122) chain X
residue 161
type
sequence D
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

123) chain X
residue 163
type
sequence G
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

124) chain X
residue 164
type
sequence S
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

125) chain X
residue 186
type
sequence E
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

126) chain X
residue 187
type
sequence K
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

127) chain X
residue 188
type
sequence A
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

128) chain X
residue 222
type
sequence D
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

129) chain X
residue 223
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

130) chain X
residue 225
type
sequence S
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

131) chain X
residue 239
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

132) chain X
residue 241
type
sequence N
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

133) chain X
residue 245
type
sequence F
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

134) chain X
residue 253
type
sequence L
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

135) chain X
residue 256
type
sequence R
description binding site for Di-peptide SAM X 500 and LEU X 224
source : AC7

136) chain X
residue 136
type BINDING
sequence Y
description
source Swiss-Prot : SWS_FT_FI1

137) chain X
residue 159
type BINDING
sequence F
description
source Swiss-Prot : SWS_FT_FI1

138) chain X
residue 186
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI1

139) chain X
residue 222
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI1

140) chain X
residue 297
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI2


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