eF-site ID 6jm9-X PDB Code 6jm9 Chain X click to enlarge Title cryo-EM structure of DOT1L bound to unmodified nucleosome Classification GENE REGULATION Compound DNA strand I Source (DOT1L_HUMAN) Sequence X:  LELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWV CEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDS IHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVTDPEK LNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGS GVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRK WMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFA FGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNL SDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILEN YFSSLKNP Description Functional site 1) chain X residue 133 type sequence P description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 2) chain X residue 135 type sequence V description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 3) chain X residue 136 type sequence Y description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 4) chain X residue 138 type sequence E description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 5) chain X residue 139 type sequence T description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 6) chain X residue 161 type sequence D description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 7) chain X residue 163 type sequence G description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 8) chain X residue 164 type sequence S description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 9) chain X residue 186 type sequence E description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 10) chain X residue 187 type sequence K description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 11) chain X residue 188 type sequence A description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 12) chain X residue 222 type sequence D description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 13) chain X residue 223 type sequence F description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 14) chain X residue 224 type sequence L description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 15) chain X residue 225 type sequence S description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 16) chain X residue 239 type sequence F description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 17) chain X residue 241 type sequence N description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 18) chain X residue 245 type sequence F description binding site for Di-peptide SAM X 500 and GLY X 137 source : AC1 19) chain X residue 133 type sequence P description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 20) chain X residue 135 type sequence V description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 21) chain X residue 136 type sequence Y description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 22) chain X residue 137 type sequence G description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 23) chain X residue 138 type sequence E description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 24) chain X residue 139 type sequence T description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 25) chain X residue 161 type sequence D description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 26) chain X residue 163 type sequence G description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 27) chain X residue 164 type sequence S description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 28) chain X residue 185 type sequence V description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 29) chain X residue 186 type sequence E description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 30) chain X residue 187 type sequence K description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 31) chain X residue 188 type sequence A description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 32) chain X residue 222 type sequence D description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 33) chain X residue 224 type sequence L description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 34) chain X residue 225 type sequence S description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 35) chain X residue 239 type sequence F description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 36) chain X residue 241 type sequence N description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 37) chain X residue 245 type sequence F description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC2 38) chain X residue 133 type sequence P description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 39) chain X residue 135 type sequence V description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 40) chain X residue 136 type sequence Y description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 41) chain X residue 137 type sequence G description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 42) chain X residue 138 type sequence E description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 43) chain X residue 139 type sequence T description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 44) chain X residue 161 type sequence D description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 45) chain X residue 163 type sequence G description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 46) chain X residue 164 type sequence S description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 47) chain X residue 185 type sequence V description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 48) chain X residue 186 type sequence E description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 49) chain X residue 187 type sequence K description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 50) chain X residue 188 type sequence A description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 51) chain X residue 222 type sequence D description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 52) chain X residue 224 type sequence L description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 53) chain X residue 225 type sequence S description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 54) chain X residue 239 type sequence F description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 55) chain X residue 241 type sequence N description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 56) chain X residue 245 type sequence F description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC3 57) chain X residue 133 type sequence P description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 58) chain X residue 135 type sequence V description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 59) chain X residue 136 type sequence Y description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 60) chain X residue 137 type sequence G description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 61) chain X residue 138 type sequence E description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 62) chain X residue 139 type sequence T description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 63) chain X residue 161 type sequence D description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 64) chain X residue 163 type sequence G description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 65) chain X residue 164 type sequence S description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 66) chain X residue 185 type sequence V description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 67) chain X residue 186 type sequence E description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 68) chain X residue 187 type sequence K description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 69) chain X residue 188 type sequence A description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 70) chain X residue 222 type sequence D description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 71) chain X residue 224 type sequence L description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 72) chain X residue 225 type sequence S description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 73) chain X residue 239 type sequence F description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 74) chain X residue 241 type sequence N description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 75) chain X residue 245 type sequence F description binding site for Di-peptide SAM X 500 and PHE X 223 source : AC4 76) chain X residue 133 type sequence P description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 77) chain X residue 135 type sequence V description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 78) chain X residue 136 type sequence Y description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 79) chain X residue 137 type sequence G description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 80) chain X residue 138 type sequence E description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 81) chain X residue 139 type sequence T description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 82) chain X residue 161 type sequence D description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 83) chain X residue 163 type sequence G description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 84) chain X residue 164 type sequence S description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 85) chain X residue 186 type sequence E description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 86) chain X residue 187 type sequence K description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 87) chain X residue 188 type sequence A description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 88) chain X residue 222 type sequence D description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 89) chain X residue 223 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 90) chain X residue 225 type sequence S description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 91) chain X residue 239 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 92) chain X residue 241 type sequence N description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 93) chain X residue 245 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 94) chain X residue 253 type sequence L description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 95) chain X residue 256 type sequence R description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC5 96) chain X residue 133 type sequence P description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 97) chain X residue 135 type sequence V description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 98) chain X residue 136 type sequence Y description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 99) chain X residue 137 type sequence G description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 100) chain X residue 138 type sequence E description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 101) chain X residue 139 type sequence T description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 102) chain X residue 161 type sequence D description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 103) chain X residue 163 type sequence G description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 104) chain X residue 164 type sequence S description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 105) chain X residue 186 type sequence E description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 106) chain X residue 187 type sequence K description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 107) chain X residue 188 type sequence A description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 108) chain X residue 222 type sequence D description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 109) chain X residue 223 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 110) chain X residue 225 type sequence S description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 111) chain X residue 239 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 112) chain X residue 241 type sequence N description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 113) chain X residue 245 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 114) chain X residue 253 type sequence L description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 115) chain X residue 256 type sequence R description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC6 116) chain X residue 133 type sequence P description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 117) chain X residue 135 type sequence V description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 118) chain X residue 136 type sequence Y description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 119) chain X residue 137 type sequence G description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 120) chain X residue 138 type sequence E description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 121) chain X residue 139 type sequence T description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 122) chain X residue 161 type sequence D description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 123) chain X residue 163 type sequence G description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 124) chain X residue 164 type sequence S description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 125) chain X residue 186 type sequence E description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 126) chain X residue 187 type sequence K description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 127) chain X residue 188 type sequence A description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 128) chain X residue 222 type sequence D description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 129) chain X residue 223 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 130) chain X residue 225 type sequence S description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 131) chain X residue 239 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 132) chain X residue 241 type sequence N description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 133) chain X residue 245 type sequence F description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 134) chain X residue 253 type sequence L description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 135) chain X residue 256 type sequence R description binding site for Di-peptide SAM X 500 and LEU X 224 source : AC7 136) chain X residue 136 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 137) chain X residue 159 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 138) chain X residue 186 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1 139) chain X residue 222 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 140) chain X residue 297 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI2

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