eF-site ID 6jlq-ABC PDB Code 6jlq Chain A, B, C click to enlarge Title Crystal structure of human USP46-WDR48-WDR20 complex Classification HYDROLASE Compound Ubiquitin carboxyl-terminal hydrolase 46 Source (L8I535_9CETA) Sequence A:  FGLVNFGNTCYCNSVLQALYFCRPFRENVLALTCLADLFH SIAIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIA DILQEEKKQELTWVHEIFQGTLTNETRCLNCETVSSKDED FLDLSVDVEQNTSITHCLRDFSNTETLCSEQKYYCETCCS KQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRV VFPLELRLFNTSSDAVNLDRMYDLVAVVVHCGSGPNRGHY ITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNS ESGYILFYQSRE B:  RKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDS IIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLIS ASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELV ASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIY SLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDN VKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHD EGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICE EKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNF NPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNN VAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVD LKTGMLTITLDESDCFAAWVSAKDAGFSDGSDPKLNLGGL LLQALLEYWPRTHQKGNGYFQVPPHTPVIFGEAGGRTLFR LLCRDSGGETESMLLNETVPQWVIDITVDKNM C:  NEIKTQFTTREGLYKLLPHSEYSRPNRVPFNSQGSNPVRV SFVNLNDQSGNGDRLCFNVGRELYFYIYKGVRKAADLSKP IDKRIYKGTQPTCHDFNHLTATAESVSLLVGFSAGQVQLI DPIKKETSKLFNEERLIDKSRVTCVKWVPGSESLFLVAHS SGNMYLYNVEHTCGTTAPHYQLLKQGESFAVHTCKSKSTR NPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFD SVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS FVDCRVIARGHGHKSWVSVVAFDPYTTSGGGSVSVTYRFG SVGQDTQLCLWDLTEDILFPHLGTPLCPRMEDVPLLEPLI CKKIAHERLTVLIFLEDCIVTACQEGFICTWGRPGKVVSF N Description Functional site 1) chain A residue 182 type sequence C description binding site for residue ZN A 401 source : AC1 2) chain A residue 185 type sequence C description binding site for residue ZN A 401 source : AC1 3) chain A residue 229 type sequence C description binding site for residue ZN A 401 source : AC1 4) chain A residue 231 type sequence T description binding site for residue ZN A 401 source : AC1 5) chain A residue 232 type sequence C description binding site for residue ZN A 401 source : AC1 6) chain A residue 256 type sequence K description binding site for residue GOL A 402 source : AC2 7) chain B residue 193 type sequence R description binding site for residue PO4 B 601 source : AC3 8) chain B residue 202 type sequence K description binding site for residue PO4 B 601 source : AC3 9) chain B residue 205 type sequence K description binding site for residue PO4 B 601 source : AC3 10) chain B residue 238 type sequence S description binding site for residue GOL B 602 source : AC4 11) chain B residue 241 type sequence Q description binding site for residue GOL B 602 source : AC4 12) chain B residue 110 type sequence M description binding site for residue GOL B 603 source : AC5 13) chain B residue 105 type sequence H description binding site for residue GOL B 604 source : AC6 14) chain B residue 261 type sequence N description binding site for residue GOL B 605 source : AC7 15) chain B residue 266 type sequence H description binding site for residue GOL B 605 source : AC7 16) chain B residue 268 type sequence Y description binding site for residue GOL B 605 source : AC7 17) chain B residue 309 type sequence P description binding site for residue GOL B 605 source : AC7 18) chain B residue 330 type sequence H description binding site for residue GOL B 605 source : AC7 19) chain B residue 139 type sequence R description binding site for residue GOL B 606 source : AC8 20) chain B residue 164 type sequence L description binding site for residue GOL B 606 source : AC8 21) chain B residue 165 type sequence S description binding site for residue GOL B 606 source : AC8 22) chain B residue 166 type sequence G description binding site for residue GOL B 606 source : AC8 23) chain B residue 167 type sequence N description binding site for residue GOL B 606 source : AC8 24) chain B residue 274 type sequence R description binding site for residue GOL B 607 source : AC9 25) chain C residue 63 type sequence D description binding site for residue GOL C 601 source : AD1 26) chain C residue 542 type sequence L description binding site for residue GOL C 601 source : AD1 27) chain C residue 544 type sequence D description binding site for residue GOL C 601 source : AD1 28) chain B residue 90-104 type prosite sequence LISASSDTTVKVWNA description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LISAssDtTVKVWNA source prosite : PS00678 29) chain B residue 132-146 type prosite sequence VASAGLDRQIFLWDV description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LISAssDtTVKVWNA source prosite : PS00678 30) chain A residue 36-51 type prosite sequence GLVNFGNTCYCNSVLQ description USP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnfGNtCYCNSvLQ source prosite : PS00972 31) chain A residue 296-314 type prosite sequence YDLVAVVVHCGSGPNRGHY description USP_2 Ubiquitin specific protease (USP) domain signature 2. YdLvAVvvHcGsgpnr.GHY source prosite : PS00973 32) chain B residue 214 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 185 type MOD_RES sequence C description N6-acetyllysine => ECO:0000250|UniProtKB:Q8BH57 source Swiss-Prot : SWS_FT_FI3 34) chain A residue 229 type MOD_RES sequence C description N6-acetyllysine => ECO:0000250|UniProtKB:Q8BH57 source Swiss-Prot : SWS_FT_FI3 35) chain A residue 232 type MOD_RES sequence C description N6-acetyllysine => ECO:0000250|UniProtKB:Q8BH57 source Swiss-Prot : SWS_FT_FI3

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