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eF-site ID
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6j71-A |
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PDB Code
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6j71 |
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Chain
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A |
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click to enlarge
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Title
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HuA21-scFv in complex with the extracellular domain(ECD) of HER2 |
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Classification
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SIGNALING PROTEIN |
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Compound
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Receptor tyrosine-protein kinase erbB-2 |
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Source
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(6J71) |
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Sequence
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A: |
STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLE
LTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRI
VRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQ
LRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLAL
TLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCA
GGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHS
GICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPY
NYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARV
CYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESF
DGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPD
LSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLREL
GSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPE
DECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECV
EECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEA
DQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEG
ACQPCPINCTHSCVDLDD
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Description
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Functional site
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1)
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chain |
A |
| residue |
182 |
| type |
MOD_RES |
| sequence |
T
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| description |
Phosphothreonine => ECO:0007744|PubMed:23186163
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
A |
| residue |
68 |
| type |
CARBOHYD |
| sequence |
N
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| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW
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| source |
Swiss-Prot : SWS_FT_FI2
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3)
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chain |
A |
| residue |
124 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI3
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4)
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chain |
A |
| residue |
629 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI3
|
|
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5)
|
chain |
A |
| residue |
187 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3N85
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| source |
Swiss-Prot : SWS_FT_FI4
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6)
|
chain |
A |
| residue |
259 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0000269|PubMed:20696930, ECO:0007744|PDB:1N8Z, ECO:0007744|PDB:1S78, ECO:0007744|PDB:2A91, ECO:0007744|PDB:3MZW, ECO:0007744|PDB:3N85
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| source |
Swiss-Prot : SWS_FT_FI5
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7)
|
chain |
A |
| residue |
530 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15093539, ECO:0000269|PubMed:19299620, ECO:0007744|PDB:1S78
|
| source |
Swiss-Prot : SWS_FT_FI6
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|
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8)
|
chain |
A |
| residue |
571 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20696930, ECO:0007744|PDB:3MZW
|
| source |
Swiss-Prot : SWS_FT_FI7
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