eF-site ID 6j5l-A PDB Code 6j5l Chain A click to enlarge Title Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10e Classification TRANSFERASE Compound High affinity nerve growth factor receptor Source (NTRK1_HUMAN) Sequence A:  SGIRVHHIKRRDIVLKWELGEGAFGKVFLAECHNLDKMLV AVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTE GRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQG LVVKIGDFGIYSTDYYRVTMLPIRWMPPESILYRKFTTES DVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELER PRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP PV Description Functional site 1) chain A residue 516 type sequence L description binding site for residue B9C A 801 source : AC1 2) chain A residue 517 type sequence G description binding site for residue B9C A 801 source : AC1 3) chain A residue 518 type sequence E description binding site for residue B9C A 801 source : AC1 4) chain A residue 521 type sequence F description binding site for residue B9C A 801 source : AC1 5) chain A residue 524 type sequence V description binding site for residue B9C A 801 source : AC1 6) chain A residue 542 type sequence A description binding site for residue B9C A 801 source : AC1 7) chain A residue 589 type sequence F description binding site for residue B9C A 801 source : AC1 8) chain A residue 590 type sequence E description binding site for residue B9C A 801 source : AC1 9) chain A residue 591 type sequence Y description binding site for residue B9C A 801 source : AC1 10) chain A residue 592 type sequence M description binding site for residue B9C A 801 source : AC1 11) chain A residue 595 type sequence G description binding site for residue B9C A 801 source : AC1 12) chain A residue 596 type sequence D description binding site for residue B9C A 801 source : AC1 13) chain A residue 610 type sequence L description binding site for residue B9C A 801 source : AC1 14) chain A residue 612 type sequence A description binding site for residue B9C A 801 source : AC1 15) chain A residue 654 type sequence R description binding site for residue B9C A 801 source : AC1 16) chain A residue 657 type sequence L description binding site for residue B9C A 801 source : AC1 17) chain A residue 668 type sequence D description binding site for residue B9C A 801 source : AC1 18) chain A residue 650 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 516-544 type prosite sequence LGEGAFGKVFLAECHNLDKMLVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGKVFlAechnllpeqdkml.....VAVK source prosite : PS00107 20) chain A residue 646-658 type prosite sequence FVHRDLATRNCLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV source prosite : PS00109 21) chain A residue 676 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI4 22) chain A residue 680 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI5 23) chain A residue 681 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15488758, ECO:0000269|PubMed:8155326 source Swiss-Prot : SWS_FT_FI5 24) chain A residue 516 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 544 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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