eF-site ID 6j20-A PDB Code 6j20 Chain A click to enlarge Title Crystal structure of the human NK1 substance P receptor Classification MEMBRANE PROTEIN Compound Substance-P receptor,Endolysin Source (NK1R_HUMAN) Sequence A:  FVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMR TVTNYFLVNLAFANASMAAFNTVVNFTYAVHNEWYYGLFY CKFHNFFPIAAVFASIWSMTAVAFDRYMAIIHPLQPRLSA TATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEW PEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGIRLW ASNIFEMLRIDEDEAEKLFNQDVDAAVRGILRNAKLKPVY DSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDE AAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYHEQVSAK RKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFI QQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFR Description Functional site 1) chain A residue 89 type sequence N description binding site for residue GBQ A 1201 source : AC1 2) chain A residue 109 type sequence N description binding site for residue GBQ A 1201 source : AC1 3) chain A residue 112 type sequence P description binding site for residue GBQ A 1201 source : AC1 4) chain A residue 113 type sequence I description binding site for residue GBQ A 1201 source : AC1 5) chain A residue 116 type sequence V description binding site for residue GBQ A 1201 source : AC1 6) chain A residue 165 type sequence Q description binding site for residue GBQ A 1201 source : AC1 7) chain A residue 182 type sequence I description binding site for residue GBQ A 1201 source : AC1 8) chain A residue 184 type sequence W description binding site for residue GBQ A 1201 source : AC1 9) chain A residue 193 type sequence E description binding site for residue GBQ A 1201 source : AC1 10) chain A residue 197 type sequence H description binding site for residue GBQ A 1201 source : AC1 11) chain A residue 200 type sequence V description binding site for residue GBQ A 1201 source : AC1 12) chain A residue 201 type sequence T description binding site for residue GBQ A 1201 source : AC1 13) chain A residue 204 type sequence I description binding site for residue GBQ A 1201 source : AC1 14) chain A residue 261 type sequence W description binding site for residue GBQ A 1201 source : AC1 15) chain A residue 264 type sequence F description binding site for residue GBQ A 1201 source : AC1 16) chain A residue 265 type sequence H description binding site for residue GBQ A 1201 source : AC1 17) chain A residue 32-54 type TRANSMEM sequence IVLWAAAYTVIVVTSVVGNVVVM description Helical; Name=1 => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 118-134 type prosite sequence ASIWSMTAVAFDRYMAI description G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIwSMTAVAFDRYMaI source prosite : PS00237 19) chain A residue 55-64 type TOPO_DOM sequence WIILAHKRMR description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 129-148 type TOPO_DOM sequence DRYMAIIHPLQPRLSATATK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 65-86 type TRANSMEM sequence TVTNYFLVNLAFANASMAAFNT description Helical; Name=2 => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 87-106 type TOPO_DOM sequence VVNFTYAVHNEWYYGLFYCK description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 23) chain A residue 170-194 type TOPO_DOM sequence TTETMPSRVVCMIEWPEHPNKIYEK description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 24) chain A residue 271-283 type TOPO_DOM sequence PYINPDLYLKKFI description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 107-128 type TRANSMEM sequence FHNFFPIAAVFASIWSMTAVAF description Helical; Name=3 => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 26) chain A residue 149-169 type TRANSMEM sequence VVICVIWVLALLLAFPQGYYS description Helical; Name=4 => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 27) chain A residue 195-219 type TRANSMEM sequence VYHICVTVLIYFLPLLVIGYAYTVV description Helical; Name=5 => ECO:0000255 source Swiss-Prot : SWS_FT_FI7 28) chain A residue 249-270 type TRANSMEM sequence MMIVVVCTFAICWLPFHIFFLL description Helical; Name=6 => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 29) chain A residue 284-308 type TRANSMEM sequence QQVYLAIMWLAMSSTMYNPIIYCCL description Helical; Name=7 => ECO:0000255 source Swiss-Prot : SWS_FT_FI9 30) chain A residue 197 type BINDING sequence H description BINDING => ECO:0000269|PubMed:8384323 source Swiss-Prot : SWS_FT_FI10 31) chain A residue 1060 type BINDING sequence F description BINDING => ECO:0000269|PubMed:8266098 source Swiss-Prot : SWS_FT_FI13 32) chain A residue 1073 type BINDING sequence S description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI14 33) chain A residue 1088 type BINDING sequence N description BINDING => ECO:0000303|PubMed:7831309 source Swiss-Prot : SWS_FT_FI14

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