eF-site ID 6ipg-A PDB Code 6ipg Chain A click to enlarge Title Post-catalytic Complex of Human DNA Polymerase Mu with Templating Cytosine and Mg-8oxodGMP Classification TRANSFERASE/DNA Compound DNA-directed DNA/RNA polymerase mu Source (6IPG) Sequence A:  MPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLL TFCRAASVLKALPSPVTTLSQLQGLPHFGEHSSRVVQELL EHGVCEEVERVRRSERYQTMKLFTQIFGVGVKTADRWYRE GLRTLDDLREQPQKLTQQQKAGLQHHQDLSTPVLRSDVDA LQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITH PKEGQEAGLLPRVMCRLQDQGLILYHQHAFERSFCIFRLP QPGSWKAVRVDLVVAPVSQFPFALLGWTGSKLFQRELRRF SRKEKGLWLNSHGLFDPEQKTFFQAASEEDIFRHLGLEYL PPEQRNA Description Functional site 1) chain A residue 330 type sequence D description binding site for residue MG A 501 source : AC1 2) chain A residue 332 type sequence D description binding site for residue MG A 501 source : AC1 3) chain A residue 330 type sequence D description binding site for residue MG A 502 source : AC2 4) chain A residue 332 type sequence D description binding site for residue MG A 502 source : AC2 5) chain A residue 418 type sequence D description binding site for residue MG A 502 source : AC2 6) chain A residue 241 type sequence T description binding site for residue NA A 503 source : AC3 7) chain A residue 243 type sequence I description binding site for residue NA A 503 source : AC3 8) chain A residue 246 type sequence V description binding site for residue NA A 503 source : AC3 9) chain A residue 319 type sequence G description binding site for residue PO4 A 504 source : AC4 10) chain A residue 320 type sequence G description binding site for residue PO4 A 504 source : AC4 11) chain A residue 323 type sequence R description binding site for residue PO4 A 504 source : AC4 12) chain A residue 330 type sequence D description binding site for residue PO4 A 504 source : AC4 13) chain A residue 332 type sequence D description binding site for residue PO4 A 504 source : AC4 14) chain A residue 325 type sequence K description binding site for residue EPE A 505 source : AC5 15) chain A residue 326 type sequence L description binding site for residue EPE A 505 source : AC5 16) chain A residue 327 type sequence Q description binding site for residue EPE A 505 source : AC5 17) chain A residue 190 type sequence P description binding site for residue EDO A 506 source : AC6 18) chain A residue 191 type sequence S description binding site for residue EDO A 506 source : AC6 19) chain A residue 192 type sequence P description binding site for residue EDO A 506 source : AC6 20) chain A residue 198 type sequence Q description binding site for residue EDO A 506 source : AC6 21) chain A residue 438 type sequence K description binding site for residue EDO A 507 source : AC7 22) chain A residue 442 type sequence R description binding site for residue EDO A 507 source : AC7 23) chain A residue 387 type sequence R description binding site for residue EDO A 508 source : AC8 24) chain A residue 445 type sequence R description binding site for residue EDO A 508 source : AC8 25) chain A residue 457 type sequence N description binding site for residue EDO A 508 source : AC8 26) chain A residue 458 type sequence S description binding site for residue EDO A 508 source : AC8 27) chain A residue 387 type sequence R description binding site for residue EDO A 509 source : AC9 28) chain A residue 433 type sequence G description binding site for residue EDO A 509 source : AC9 29) chain A residue 434 type sequence W description binding site for residue EDO A 509 source : AC9 30) chain A residue 445 type sequence R description binding site for residue EDO A 509 source : AC9 31) chain A residue 458 type sequence S description binding site for residue EDO A 509 source : AC9 32) chain A residue 330 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 332 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 418 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 433 type SITE sequence G description Responsible for the low discrimination between dNTP and rNTP source Swiss-Prot : SWS_FT_FI2 36) chain A residue 319-338 type prosite sequence GGFRRGKLQGHDVDFLITHP description DNA_POLYMERASE_X DNA polymerase family X signature. GGFrRGklqGhDVDFLIthP source prosite : PS00522

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